Alomone Labs, LTD

NGF/proNGF Neutralizing Monoclonal Antibody (HAL06)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ALM-006-250UG

Applications
Tested Dilution
Publications

ELISA (ELISA)

2 µg/ml
-

Neutralization (Neu)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

HAL06

Immunogen

Highly purified 2.5S mouse NGF, Secreted
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 50 µL or 0.25 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

NGF (Nerve Growth Factor) is a Protein Coding gene. Diseases associated with NGF include Neuropathy, Hereditary Sensory And Autonomic, Type V and Autonomic Neuropathy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and obsolete signal transducer activity, downstream of receptor. An important paralog of this gene is NTF3. proNGF is abundant in central nervous system tissues whereas mature NGF is undetectable, suggesting that proNGF may have a function distinct from its role as a precursor. Studies suggest that proNGF has apoptotic activity which contrast with other data demonstrating that proNGF has neurotrophic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Beta-nerve growth factor; Beta-NGF; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta subunit; proNGF

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Gene Aliases: Beta-NGF; HSAN5; NGF; NGFB

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UniProt ID: (Human) P01138, (Mouse) P01139, (Rat) P25427

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Entrez Gene ID: (Human) 4803, (Mouse) 18049, (Rat) 310738

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Function(s)
nerve growth factor receptor binding protein binding growth factor activity metalloendopeptidase inhibitor activity enzyme inhibitor activity receptor signaling protein activity receptor binding peptidase inhibitor activity molecular_function
Process(es)
transmembrane receptor protein tyrosine kinase signaling pathway cell-cell signaling peripheral nervous system development memory positive regulation of cell proliferation adult locomotory behavior extrinsic apoptotic signaling pathway via death domain receptors negative regulation of peptidase activity positive regulation of gene expression negative regulation of endopeptidase activity positive regulation of neuron projection development positive regulation of neuron maturation sensory perception of pain positive regulation of cell growth neuron projection development positive regulation of protein ubiquitination positive regulation of protein autophosphorylation intracellular signal transduction nerve growth factor signaling pathway negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of axon extension regulation of neurotransmitter secretion positive regulation of collateral sprouting neuron projection morphogenesis positive regulation of sequence-specific DNA binding transcription factor activity regulation of release of sequestered calcium ion into cytosol positive regulation of neurotrophin TRK receptor signaling pathway neuron apoptotic process cellular response to acid chemical extrinsic apoptotic signaling pathway in absence of ligand positive regulation of stem cell proliferation negative regulation of type B pancreatic cell apoptotic process activation of MAPKK activity activation of cysteine-type endopeptidase activity involved in apoptotic process microtubule-based movement nerve growth factor processing positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of Ras protein signal transduction neurotrophin TRK receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of axonogenesis inflammatory response aging circadian rhythm response to radiation response to mechanical stimulus response to organic substance response to ozone response to organic cyclic compound response to lipopolysaccharide response to nicotine response to drug response to peptide hormone response to glucocorticoid response to electrical stimulus
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