Alomone Labs, LTD

NGL-2/LRRC4 (extracellular) Polyclonal Antibody

View all (8) LRRC4 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

ANR-162-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)STDTTDKMQTSLDE, corresponding to amino acid residues 507-520 of mouse LRRC4, Extracellular, N-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The LRRC4 gene, also known as netrin-G ligand 2 (NGL-2), is a brain-specific member of the leucine-rich repeat superfamily, playing a critical role in the central nervous system. Its expression is particularly high in areas such as the hippocampal CA1 and CA2 regions, as well as in granule cells of the dentate gyrus. LRRC4 is a known tumor suppressor gene associated with glioma suppression, as it regulates glioma cell growth, angiogenesis, and invasion through extensive signaling networks. It can participate in multiphase loops involving miRNA, transcription factors, and gene methylation modifications. This gene targets various genes involved in cell motility, impacting glioblastoma cell movement and polarization by binding to enhancer elements and activating transcription, notably the RAP1GAP gene. Its function and expression are crucial in maintaining normal brain function and hold potential implications in the management of gliomagenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: brain tumor associated protein LRRC4; Brain tumor-associated protein BAG; Brain tumor-associated protein MBAG1; leucine rich repeat containing 4 protein; leucine-rich repeat-containing 4; Leucine-rich repeat-containing protein 4; LIBG-like protein; LRRC4-like protein; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin-G2 ligand; NGL-2; NLG2; protein NGL-2

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Gene Aliases: BAG; LRRC4; MBAG1; NAG14; NGL-2; NLG-2; UNQ554/PRO1111

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UniProt ID: (Human) Q9HBW1, (Mouse) Q99PH1, (Rat) Q45R42

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Entrez Gene ID: (Human) 64101, (Mouse) 192198, (Rat) 641521

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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