Proteintech

NHE3 Polyclonal Antibody

NHE3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

NHE3 Antibody (27190-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse kidney tissue slide using 27190-1-AP ( NHE3 antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9). Arrows show brush border.

NHE3 Antibody in Immunoprecipitation (IP)

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Product Details

27190-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NHE3 Fusion Protein Ag25637 (665-834 aa encoded by BC101669)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.57 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KSTKLGLNQ NKKAAKLYKR ERAQKRRNSS IPNGKLPMES PAQNFTIKEK DLELSDTEEP PNYDEEMSGG IEFLASVTKD TASDSPAGID NPVFSPDEAL DRSLLARLPP WLSPGETVVP SQRARTQIPY SPGTFRRLMP FRLSSKSVDS FLQADGPEER PPAALPESTH M (665-834 aa encoded by BC101669)

Target Information

NHE3 (also known as SLC9A3 - Sodium/hydrogen exchanger 3) is a member of the sodium/hydrogen exchanger family that plays a crucial role in acid-base and volume homeostasis by mediating the majority of sodium and bicarbonate reabsorption in the proximal tubule of the kidney. Mutations in the gene can lead to Diarrhea 8.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy.

Clinical science (London, England : 1979)

Vergara A,Llorens-Cebrià C,Martos N,Martínez-Díaz I,Stein F,Domínguez-Báez P,Molina-Van den Bosch M,Rettel M,Benito B,Bermejo S,Pieper MP,Jacobs-Cachá C,Soler MJ

Fri Jan 13 00:00:00 UTC 2023

The membrane-associated protein 17 (MAP17) is up-regulated in response to empagliflozin on top of RAS blockade in experimental diabetic nephropathy.

Clinical science (London, England : 1979)

Vergara A,Llorens-Cebrià C,Martos N,Martínez-Díaz I,Stein F,Domínguez-Báez P,Molina-Van den Bosch M,Rettel M,Benito B,Bermejo S,Pieper MP,Jacobs-Cachá C,Soler MJ

Fri Jan 13 00:00:00 UTC 2023

Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.

Molecular oncology

Chen T,Zhang X,Ding X,Feng J,Zhang X,Xie D,Wang X

Sat Apr 01 00:00:00 UTC 2023

EPA and DHA differentially coordinate the crosstalk between host and gut microbiota and block DSS-induced colitis in mice by a reinforced colonic mucus barrier.

Food & function

Fang J,Zhang Z,Cheng Y,Yang H,Zhang H,Xue Z,Lu S,Dong Y,Song C,Zhang X,Zhou Y

Wed Apr 20 00:00:00 UTC 2022

Renal Natriuretic Peptide Receptor-C Deficiency Attenuates NaCl Cotransporter Activity in Angiotensin II-Induced Hypertension.

Hypertension (Dallas, Tex. : 1979)

Shao S,Li XD,Lu YY,Li SJ,Chen XH,Zhou HD,He S,Guo YT,Lu X,Gao PJ,Wang JG

Wed Mar 03 00:00:00 UTC 2021

Effects of Guava (Psidium guajava L.) Leaf Extract on the Metabolomics of Serum and Feces in Weaned Piglets Challenged by Escherichia coli.

Frontiers in veterinary science

Wang D,Zhou L,Zhou H,Hou G

Sat Jun 12 00:00:00 UTC 2021

Podocyte Injury Augments Intrarenal Angiotensin II Generation and Sodium Retention in a Megalin-Dependent Manner.

Hypertension (Dallas, Tex. : 1979)

Koizumi M,Ueda K,Niimura F,Nishiyama A,Yanagita M,Saito A,Pastan I,Fujita T,Fukagawa M,Matsusaka T

Sun Sep 01 00:00:00 UTC 2019

Bioinformatics

Protein Aliases: MGC126718; MGC126720; Na(+)/H(+) exchanger 3; NHE-3; NHE-3 antibody; SLC9A3 antibody; Sodium/hydrogen exchanger 3; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3; solute carrier family 9 (sodium/hydrogen exchanger), member 3; Solute carrier family 9 member 3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3

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Gene Aliases: 9030624O13Rik; AI930210; DIAR8; NHE-3; NHE3; SLC9A3

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UniProt ID: (Human) P48764, (Mouse) G3X939

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Entrez Gene ID: (Human) 6550, (Mouse) 105243

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Function(s)

protein binding sodium:proton antiporter activity potassium:proton antiporter activity PDZ domain binding

Process(es)

regulation of sodium ion transport ion transport receptor-mediated endocytosis circadian rhythm response to glucocorticoid regulation of intracellular pH potassium ion transmembrane transport sodium ion import across plasma membrane hydrogen ion transmembrane transport sodium ion transport regulation of pH sodium ion transmembrane transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NHE3 Polyclonal Antibody

NHE3 Antibody (27190-1-AP) in IHC (P)

Product Details

27190-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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