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Product Details
PA5-17574
Product Specifications
Species Reactivity
Bovine,
Horse,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues adjacent to glycine 659 of human NIK
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10987415
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
MAP3K14 (NIK) is structurally related to MAP3Ks. MAP3K14 phosphorylates and activates CHUK (IKKalpha) and IKBKB (IKK beta), which in turn phosphorylate IkB-alpha, releasing NF-KappaB leading to up-regulation of inflammatory response genes. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alymphoplasia; HsNIK; Mitogen-activated protein kinase kinase kinase 14; NF kappa B-inducing kinase; NF-kappa-beta-inducing kinase; Nfkb inducing kinase; protein kinase; Serine/threonine-protein kinase NIK
Gene Aliases: aly; BOS_19310; FTDCR1B; HS; HSNIK; MAP3K14; NIK
UniProt ID: (Human) Q99558, (Mouse) Q9WUL6
Entrez Gene ID: (Bovine) 508367, (Human) 9020, (Rat) 360640, (Mouse) 53859
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
NF-kappaB-inducing kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
MAP kinase kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
MAPK cascade
activation of MAPKK activity
immune response
I-kappaB kinase/NF-kappaB signaling
T cell costimulation
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to mechanical stimulus
activation of MAPK activity
protein phosphorylation
signal transduction by protein phosphorylation
intracellular signal transduction
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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