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Invitrogen
NKG2D Recombinant Mouse Monoclonal Antibody (6E5A7)
Product Details
MA5-51823
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6E5A7
Immunogen
The original antibody was generated by immunizing BALB/c mice with soluble NKG2-D fragments containing amino acids from 64-462 and 123-462.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.02% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3250515
Product Specific Information
This antibody recognizes and binds the extracellular epitope of NKG2D and blocks the interaction between ligand and receptor.
Target Information
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. NK cells can regulate specific humoral and cell-mediated immunity, and preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NK gene encodes a member of the NKG2 family, and the encoded transmembrane protein is characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD314; Killer cell lectin-like receptor subfamily K member 1; killer cell lectin-like receptor subfamily K, member 1; natural killer cell receptor; NK cell receptor D; NKG2-D type II integral membrane protein; NKG2-D-activating NK receptor
Gene Aliases: CD314; D12S2489E; KLR; KLRK1; NKG2-D; NKG2D
UniProt ID: (Human) P26718
Entrez Gene ID: (Human) 22914
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
signal transduction
natural killer cell activation
cell differentiation
positive regulation of myeloid dendritic cell activation
T cell costimulation
positive regulation of interferon-gamma production
negative regulation of GTPase activity
positive regulation of apoptotic process
innate immune response
positive regulation of nitric oxide biosynthetic process
positive regulation of natural killer cell mediated cytotoxicity
regulation of immune response
defense response to Gram-positive bacterium
cellular response to lipopolysaccharide
negative regulation of natural killer cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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