Abnova

NKX2-5 Monoclonal Antibody (3E3)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00001482-M08

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

3E3

Immunogen

NKX2-5 (NP_004378, 1 a.a. approximately 130 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MFPSPALTPT PFSVKDILNL EQQQRSLAAA GELSARLEAT LAPSSCMLAA FKPEAYAGPE AAAPGLPELR AELGRAPSPA KCASAFPAAP AFYPRAYSDP DPAKDPRAEK KELCALQKAV ELEKTEADNA *

Target Information

This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cardiac-specific homeobox; cardiac-specific homeobox 1; FLJ52202; FLJ97166; FLJ97195; FLJ97197; FLJ99536; Homeobox protein CSX; Homeobox protein NK-2 homolog E; homeobox protein NKX 2-5; Homeobox protein Nkx-2.5; NK2 transcription factor related locus 5; NK2 transcription factor related, locus 5; NKX 2-5; Nkx-25; tinman paralog

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Gene Aliases: CHNG5; CSX; CSX1; HLHS2; NKX2-5; NKX2.5; NKX2E; NKX4-1; VSD3

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UniProt ID: (Human) P52952

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Entrez Gene ID: (Human) 1482

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription cofactor activity transcriptional activator activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding transcription factor binding serum response element binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter vasculogenesis heart looping heart morphogenesis outflow tract septum morphogenesis cardiac conduction system development bundle of His development Purkinje myocyte differentiation cardiac ventricle formation right ventricular cardiac muscle tissue morphogenesis ventricular trabecula myocardium morphogenesis apoptotic process involved in heart morphogenesis septum secundum development proepicardium development pulmonary myocardium development transcription from RNA polymerase II promoter adult heart development positive regulation of cell proliferation negative regulation of cardiac muscle cell apoptotic process positive regulation of transcription via serum response element binding positive regulation of sodium ion transport negative regulation of myotube differentiation hemopoiesis cell differentiation BMP signaling pathway thyroid gland development embryonic heart tube development negative regulation of apoptotic process sarcomere organization positive regulation of neuron differentiation positive regulation of heart contraction negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development positive regulation of cardioblast differentiation ventricular cardiac myofibril assembly cardiac muscle cell differentiation cardiac muscle tissue morphogenesis atrial cardiac muscle cell development ventricular cardiac muscle cell development regulation of cardiac muscle contraction pharyngeal system development cardiac muscle cell proliferation regulation of cardiac muscle cell proliferation cardiac muscle contraction canonical Wnt signaling pathway positive regulation of transcription initiation from RNA polymerase II promoter heart trabecula formation ventricular septum morphogenesis atrial septum morphogenesis atrioventricular node cell development atrioventricular node cell fate commitment embryonic heart tube left/right pattern formation negative regulation of canonical Wnt signaling pathway regulation of cardiac conduction
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