Abnova

NKX3-1 Monoclonal Antibody (1C7)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00004824-M02

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

Immunocytochemistry (ICC/IF)

10-100 µg/mL
-

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1C7

Immunogen

NKX3-1 (NP_006158, 100 a.a. approximately 209 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Product may be used with Western Blot (Cell lysate).

Immunogen sequence: GSYLLDSENT SGALPRLPQT PKQPQKRSRA AFSHTQVIEL ERKFSHQKYL SAPERAHLAK NLKLTETQVK IWFQNRRYKT KRKQLSSELG DLEKHSSLPA LKEEAFSRAS

Target Information

The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Drosophila NK-3 transcription factor, locus 1; Homeobox protein NK-3 homolog A; Homeobox protein Nkx-3.1; NK homeobox, family 3, A; NK-3 transcription factor, locus 1; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3-1 antibody; prostate-specific ag

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Gene Aliases: bagpipe; BAPX2; Bax; Nkx-3.1; NKX3; NKX3-1; NKX3.1; NKX3A

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UniProt ID: (Human) Q99801, (Mouse) P97436

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Entrez Gene ID: (Human) 4824, (Mouse) 18095, (Rat) 305999

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Function(s)
transcription regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific core promoter binding transcription factor activity, sequence-specific DNA binding androgen receptor activity protein binding transcription factor binding cysteine-type endopeptidase activator activity involved in apoptotic process estrogen receptor activity protein kinase activator activity estrogen receptor binding histone deacetylase binding sequence-specific DNA binding protein self-association transcription regulatory region DNA binding MADS box domain binding DNA binding
Process(es)
urogenital system development positive regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter activation of cysteine-type endopeptidase activity involved in apoptotic process multicellular organism development salivary gland development positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression positive regulation of cell death positive regulation of phosphatidylinositol 3-kinase signaling androgen receptor signaling pathway prostate gland development response to testosterone internal genitalia morphogenesis positive regulation of cysteine-type endopeptidase activity involved in apoptotic process steroid hormone mediated signaling pathway protein kinase B signaling negative regulation of insulin-like growth factor receptor signaling pathway positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter branching morphogenesis of an epithelial tube negative regulation of epithelial cell proliferation positive regulation of cell division branching involved in prostate gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis negative regulation of epithelial cell proliferation involved in prostate gland development cellular response to steroid hormone stimulus cellular response to hypoxia mitotic cell cycle arrest negative regulation of estrogen receptor binding positive regulation of androgen secretion positive regulation of response to DNA damage stimulus positive regulation of apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway metanephros development somitogenesis heart development male gonad development activation of protein kinase activity cellular response to drug dorsal aorta development pharyngeal system development cellular response to interleukin-1 cellular response to tumor necrosis factor
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