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Product Details
16419-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NLE1 Fusion Protein Ag9604 (137-485 aa encoded by BC012075)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: TVRFWDLST ETPHFTCKGH RHWVLSISWS PDGKKLASGC KNGQILLWDP STGKQVGRTL AGHSKWITGL SWEPLHANPE CRYVASSSKD GSVRIWDTTA GRCERILTGH TQSVTCLRWG GDGLLYSASQ DRTIKVWRAH DGVLCRTLQG HGHWVNTMAL STDYALRTGA FEPAEASVNP QDLQGSLQEL KERALSRYNL VRGQGPERLV SGSDDFTLFL WSPAEDKKPL TRMTGHQALI NQVLFSPDSR IVASASFDKS IKLWDGRTGK YLASLRGHVA AVYQIAWSAD SRLLVSGSSD STLKVWDVKA QKLAMDLPGH ADEVYAVDWS PDGQRVASGG KDKCLRIWRR (137-485 aa encoded by BC012075)
Target Information
NLE1 plays a role in regulating Notch activity, in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. NLE1 is required during embryogenesis for inner mass cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ10458; Notchless gene homolog; Notchless protein homolog 1; novel WD40 repeat containing protein
Gene Aliases: AL022765; BC018399; HUSSY-07; l11Jus1; l11Jus4; Nle; NLE1; RGD1308301
UniProt ID: (Human) Q9NVX2, (Mouse) Q8VEJ4
Entrez Gene ID: (Human) 54475, (Rat) 303372, (Mouse) 217011
somitogenesis
kidney development
inner cell mass cell differentiation
Notch signaling pathway
ribosomal large subunit biogenesis
negative regulation of mitotic cell cycle
skeletal system morphogenesis
hematopoietic stem cell homeostasis
positive regulation of canonical Wnt signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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