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NLRP1 Polyclonal Antibody

NLRP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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NLRP1 Antibody (12256-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 12256-1-AP) (NLRP1 antibody) at dilution of 1:200 (under 10x lens. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

12256-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NLRP1 Fusion Protein Ag2908 (1-146 aa encoded by BC016965)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPLDPYHSV TWGHAQGSHH FVFGELRVRP ILESLRDEPD PDPRPSREGP AGRVGALARG GPEPCDAASP PGGASCAPEL ARPREDKSAQ QAKLEGGTRL CCRCPEESRL VPGGAVSPGD HVLEVSGTRG TCGCRPRRHA GPELAHS (1-146 aa encoded by BC016965)

Target Information

NALP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.

Neurotoxicity research

Liu X,Song W,Yu Y,Su J,Shi X,Yang X,Wang H,Liu P,Zou L

Sat Oct 01 00:00:00 UTC 2022

Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats.

Neurotoxicity research

Liu X,Song W,Yu Y,Su J,Shi X,Yang X,Wang H,Liu P,Zou L

Sat Oct 01 00:00:00 UTC 2022

Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP.

Inflammation

Ji Q,Wang L,Liu J,Wu Y,Lv H,Wen Y,Shi L,Qu B,Szentmáry N

Thu Apr 01 00:00:00 UTC 2021

Porphyromonas gingivalis-Induced NLRP3 Inflammasome Activation and Its Downstream Interleukin-1β Release Depend on Caspase-4.

Frontiers in microbiology

Ding PH,Yang MX,Wang NN,Jin LJ,Dong Y,Cai X,Chen LL

Mon Sep 28 00:00:00 UTC 2020

Overexpression of MicroRNA-9a-5p Ameliorates NLRP1 Inflammasome-mediated Ischemic Injury in Rats Following Ischemic Stroke.

Neuroscience

Cao Y,Zhang H,Lu X,Wang J,Zhang X,Sun S,Bao Z,Tian W,Ning S,Wang L,Cui L

Tue Sep 15 00:00:00 UTC 2020

Overexpression of MicroRNA-9a-5p Ameliorates NLRP1 Inflammasome-mediated Ischemic Injury in Rats Following Ischemic Stroke.

Neuroscience

Cao Y,Zhang H,Lu X,Wang J,Zhang X,Sun S,Bao Z,Tian W,Ning S,Wang L,Cui L

Tue Sep 15 00:00:00 UTC 2020

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.

Frontiers in immunology

Guo Q,Wu Y,Hou Y,Liu Y,Liu T,Zhang H,Fan C,Guan H,Li Y,Shan Z,Teng W

Fri Aug 16 00:00:00 UTC 2019

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.

Frontiers in immunology

Guo Q,Wu Y,Hou Y,Liu Y,Liu T,Zhang H,Fan C,Guan H,Li Y,Shan Z,Teng W

Fri Aug 16 00:00:00 UTC 2019

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.

Frontiers in immunology

Guo Q,Wu Y,Hou Y,Liu Y,Liu T,Zhang H,Fan C,Guan H,Li Y,Shan Z,Teng W

Fri Aug 16 00:00:00 UTC 2019

Cytokine Secretion and Pyroptosis of Thyroid Follicular Cells Mediated by Enhanced NLRP3, NLRP1, NLRC4, and AIM2 Inflammasomes Are Associated With Autoimmune Thyroiditis.

Frontiers in immunology

Guo Q,Wu Y,Hou Y,Liu Y,Liu T,Zhang H,Fan C,Guan H,Li Y,Shan Z,Teng W

Fri Aug 16 00:00:00 UTC 2019

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

mBio

Bando H,Lee Y,Sakaguchi N,Pradipta A,Ma JS,Tanaka S,Cai Y,Liu J,Shen J,Nishikawa Y,Sasai M,Yamamoto M

Tue Oct 09 00:00:00 UTC 2018

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.

mBio

Bando H,Lee Y,Sakaguchi N,Pradipta A,Ma JS,Tanaka S,Cai Y,Liu J,Shen J,Nishikawa Y,Sasai M,Yamamoto M

Tue Oct 09 00:00:00 UTC 2018

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.

Molecular neurodegeneration

Saresella M,La Rosa F,Piancone F,Zoppis M,Marventano I,Calabrese E,Rainone V,Nemni R,Mancuso R,Clerici M

Thu Mar 03 00:00:00 UTC 2016

The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease.

Molecular neurodegeneration

Saresella M,La Rosa F,Piancone F,Zoppis M,Marventano I,Calabrese E,Rainone V,Nemni R,Mancuso R,Clerici M

Thu Mar 03 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: caspase recruitment domain protein; caspase recruitment domain protein 7; Caspase recruitment domain-containing protein 7; Death effector filament-forming ced-4-like apoptosis protein; DKFZp586O1822; nacht; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NACHT, LRR and PYD domains-containing protein 1a; NACHT/LRR/pyrin domain-containing protein 1; NLR family, pyrin domain containing 1; NLR family, pyrin domain containing 1A; Nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1

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Gene Aliases: CARD7; CIDED; CLR17.1; DEFCAP; DEFCAP-L/S; Gm14; Gm15; KIAA0926; NAC; NALP1; Nalp1a; NLRP1; Nlrp1a; PP1044; SLEV1; VAMAS1

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UniProt ID: (Human) Q9C000, (Mouse) Q2LKU9

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Entrez Gene ID: (Human) 22861, (Mouse) 195046

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Function(s)

protein binding ATP binding cysteine-type endopeptidase activator activity involved in apoptotic process enzyme binding protein domain specific binding scaffold protein binding

Process(es)

response to muramyl dipeptide defense response to bacterium positive regulation of interleukin-1 beta secretion programmed necrotic cell death apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response innate immune response regulation of inflammatory response neuron apoptotic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NLRP1 Polyclonal Antibody

NLRP1 Antibody (12256-1-AP) in IHC (P)

Product Details

12256-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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