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NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP14 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP14, it has been suggested that it may play a role in spermatogenesis and that mutations in the NALP14 gene might cause spermatogenic failure.
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Protein Aliases: Germ cell specific leucine-rich repeat NTPase; germ-cell specific leucine rich repeat NTPase; NACHT, leucine rich repeat and PYD containing 14; NACHT, LRR and PYD containing protein 14; NACHT, LRR and PYD domains-containing protein 14; NALP-iota; NLR family, pyrin domain containing 14; Nucleotide-binding oligomerization domain protein 5; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 14; RNI-like protein
Gene Aliases: 4921520L01Rik; CLR11.2; GC-LRR; Nalp-iota; NALP14; Nalp14l; NLRP14; NOD5; PAN8
UniProt ID: (Human) Q86W24, (Mouse) Q6B966
Entrez Gene ID: (Human) 338323, (Mouse) 76858
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