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Product Details
PA5-88709
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-220 of human NLRP3 (NP_0011209341)
Conjugate
Form
Liquid
Concentration
1.83 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805084
Product Specific Information
Positive Samples: U-937; Cellular Location: Cytoplasm, Endoplasmic reticulum, Inflammasome, Nucleus, cytosol
Immunogen sequence: MKMASTRCKL ARYLEDLEDV DLKKFKMHLE DYPPQKGCIP LPRGQTEKAD HVDLATLMID FNGEEKAWAM AVWIFAAINR RDLYEKAKRD EPKWGSDNAR VSNPTVICQE DSIEEEWMGL LEYLSRISIC KMKKDYRKKY RKYVRSRFQC IEDRNARLGE SVSLNKRYTR LRLIKEHRSQ QEREQELLAI GKTKTCESPV SPIKMELLFD PDDEHSEPVH
Target Information
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; CLR1.1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein; Cold autoinflammatory syndrome 1 protein homolog; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; FLJ95925; mast cell maturation inducible protein 1; Mast cell maturation-associated-inducible protein 1; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NLR family, pyrin domain containing 3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYRIN-containing APAF1-like protein 1
Gene Aliases: AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1; CLR1.1; FCAS; FCAS1; FCU; Mmig1; MWS; NALP3; NLRP3; PYPAF1
UniProt ID: (Human) Q96P20, (Rat) D4A523, (Mouse) Q8R4B8
Entrez Gene ID: (Human) 114548, (Rat) 287362, (Mouse) 216799
negative regulation of acute inflammatory response
positive regulation of type 2 immune response
transcription, DNA-templated
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
defense response
inflammatory response
signal transduction
detection of biotic stimulus
negative regulation of NF-kappaB transcription factor activity
interleukin-1 beta production
interleukin-18 production
positive regulation of interleukin-13 production
positive regulation of interleukin-4 production
positive regulation of interleukin-5 production
negative regulation of NF-kappaB import into nucleus
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
NLRP3 inflammasome complex assembly
innate immune response
positive regulation of T-helper 2 cell differentiation
positive regulation of transcription from RNA polymerase II promoter
interleukin-1 secretion
negative regulation of interleukin-1 beta secretion
positive regulation of interleukin-1 beta secretion
negative regulation of inflammatory response
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
defense response to virus
cellular response to lipopolysaccharide
positive regulation of T-helper 17 cell differentiation
positive regulation of T-helper 2 cell cytokine production
biological_process
regulation of inflammatory response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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