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Invitrogen
NMDAR1 Polyclonal Antibody
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NMDAR1 Antibody (PA5-34599) in IHC
Immunofluorescence was performed on sections of adult rat hippocampus. Tissue sections on slides were probed for 24 hours at 4°C in a humidified chamber with rabbit polyclonal anti- NMDAR1 (Product # PA5-34599) at an antibody concentration of 1-2 µg/mL diluted in 50 mM Tris-HCl, pH 7.4, containing 1.5% NaCl, 0.3% Triton X-100 (TBST) and 4% normal goat serum. After overnight incubation, sections were washed extensively for 1 hour in TBST, and detection of primary antibody was performed for 1.5 hours at room temperature with AlexaFluor-488-c... View More
Product Details
PA5-34599
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Mouse,
Rat,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Rat NMDAR1.
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2551951
Product Specific Information
For Western Blot, this antibody has non-specific bands at 54 kDa.
This antibody is predicted to react with mouse and human based on sequence homology.
Target Information
NMDAR1 encodes a protein that is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GluN1; Glun1r; Glutamate [NMDA] receptor subunit zeta-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 1; N-methyl-D-aspartate glutamate receptor; N-methyl-D-aspartate receptor subunit NR1; neurotransmitter receptor; NMD-R1; NMDA R1 receptor C1 cassette; NMDA receptor 1; NMDZ1; NMZ1; NR1C1; NR1C2; NR1C2'; NR1N1; pGluN1; RP11-350O14.1
Gene Aliases: GluN1; Grin1; NMDAR1; NR1
UniProt ID: (Rat) P35439
Entrez Gene ID: (Rat) 24408
ionotropic glutamate receptor activity
NMDA glutamate receptor activity
receptor binding
extracellular-glutamate-gated ion channel activity
cation channel activity
calcium channel activity
calcium ion binding
protein binding
calmodulin binding
glycine binding
glutamate binding
enzyme binding
voltage-gated cation channel activity
glutamate receptor binding
neurotransmitter binding
protein heterodimerization activity
protein dimerization activity
conditioned taste aversion
startle response
suckling behavior
response to amphetamine
cation transport
calcium ion transport
cellular calcium ion homeostasis
respiratory gaseous exchange
learning or memory
learning
memory
long-term memory
associative learning
adult locomotory behavior
olfactory learning
visual learning
regulation of cell communication
positive regulation of cell death
response to organic cyclic compound
response to amine
propylene metabolic process
sensory perception of pain
pons maturation
cerebral cortex development
ion transmembrane transport
regulation of ion transmembrane transport
social behavior
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
regulation of membrane potential
positive regulation of apoptotic process
response to morphine
regulation of neuron apoptotic process
negative regulation of neuron apoptotic process
regulation of respiratory gaseous exchange
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
regulation of synaptic plasticity
regulation of neuronal synaptic plasticity
regulation of long-term neuronal synaptic plasticity
rhythmic process
regulation of dendrite morphogenesis
regulation of axonogenesis
neuromuscular process
protein tetramerization
response to calcium ion
regulation of synapse assembly
calcium ion homeostasis
excitatory postsynaptic potential
prepulse inhibition
male mating behavior
response to fungicide
calcium ion transmembrane transport
cellular response to manganese ion
positive regulation of excitatory postsynaptic potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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