Invitrogen

NMDAR2A Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-85391

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the Intracellular domain of human NMDAR2A. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

0.1M tris glycine, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2792533

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (90%), Rat (90%), Chimpanzee (98%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor; Glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; NMDAR2A; OTTHUMP00000160135; OTTHUMP00000174531

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Gene Aliases: EPND; FESD; GluN2A; GRIN2A; LKS; NMDAR2A; NR2A

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UniProt ID: (Human) Q12879, (Rat) Q00959

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Entrez Gene ID: (Human) 2903, (Rat) 24409

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Function(s)
NMDA glutamate receptor activity Ras guanyl-nucleotide exchange factor activity extracellular-glutamate-gated ion channel activity calcium channel activity protein binding zinc ion binding ionotropic glutamate receptor activity receptor binding cation channel activity glutamate binding protein kinase binding voltage-gated cation channel activity protein complex binding glutamate receptor binding neurotransmitter binding protein heterodimerization activity protein dimerization activity cell adhesion molecule binding ATPase binding scaffold protein binding
Process(es)
MAPK cascade startle response response to amphetamine transport glutamate receptor signaling pathway chemical synaptic transmission learning or memory memory protein localization visual learning response to wounding sensory perception of pain neurogenesis sleep directional locomotion ionotropic glutamate receptor signaling pathway negative regulation of protein catabolic process dopamine metabolic process serotonin metabolic process response to drug positive regulation of apoptotic process positive regulation of GTPase activity response to ethanol regulation of sensory perception of pain excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport positive regulation of long-term synaptic potentiation action potential cation transport calcium ion transport learning response to light stimulus response to carbohydrate response to manganese ion positive regulation of cell death response to organic cyclic compound response to amine spinal cord development hippocampus development cerebral cortex development ion transmembrane transport regulation of ion transmembrane transport synaptic transmission, glutamatergic locomotion response to cocaine regulation of membrane potential regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity rhythmic process modulation of synaptic transmission detection of mechanical stimulus involved in sensory perception of pain protein tetramerization response to calcium ion response to methylmercury response to other organism regulation of postsynaptic membrane potential response to ammonium ion response to fungicide cellular response to amino acid stimulus cellular response to magnesium ion cellular response to manganese ion cellular response to zinc ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid cation transmembrane transport positive regulation of excitatory postsynaptic potential
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