Invitrogen

NMDAR2B Chimeric Recombinant Rabbit Monoclonal Antibody (17)

View all (49) NMDAR2B antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-51624

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

10 µg/mL
-

Flow Cytometry (Flow)

1:100
-

In vitro Assay (IV)

Assay-dependent
-
Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

17

Immunogen

Monoclonal antibodies that bind rat GluN2B ATD were obtained by immunizing mice with the purified intact GluN1-GluN2B NMDA receptors.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

0.02% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3250323

Product Specific Information

Reacts specifically with rat GluN2B ATD.

Target Information

NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death. Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression. Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity. NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3. Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GluN2B; Glutamate [NMDA] receptor subunit epsilon-2; glutamate receptor; Glutamate receptor ionotropic, NMDA 2B; glutamate receptor, ionotropic, NMDA2B; GRIN 2B; HGNC:4586; hNR 3; MGC142178; MGC142180; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; NMDE2; NME2; NR2B

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Gene Aliases: GluN2B; Grin2b

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UniProt ID: (Rat) Q00960

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Entrez Gene ID: (Rat) 24410

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Function(s)
ionotropic glutamate receptor activity NMDA glutamate receptor activity receptor binding interleukin-1 receptor binding extracellular-glutamate-gated ion channel activity cation channel activity calcium channel activity protein binding beta-catenin binding drug binding zinc ion binding glycine binding D2 dopamine receptor binding ionotropic glutamate receptor binding neurotransmitter binding protein heterodimerization activity cell adhesion molecule binding
Process(es)
action potential behavioral fear response in utero embryonic development startle response suckling behavior response to amphetamine cation transport calcium ion transport chemical synaptic transmission sensory organ development learning or memory learning memory long-term memory associative learning response to mechanical stimulus response to toxic substance response to carbohydrate response to manganese ion cellular response to magnesium starvation regulation of protein kinase A signaling positive regulation of cell death positive regulation of glutamate secretion response to organic cyclic compound response to amine hippocampus development cerebral cortex development response to magnesium ion multicellular organismal response to stress response to cytokine ion transmembrane transport ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic response to cocaine fear response receptor clustering regulation of MAPK cascade response to ethanol regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity behavioral response to pain rhythmic process positive regulation of synaptic transmission detection of mechanical stimulus involved in sensory perception of pain response to calcium ion response to methylmercury response to electrical stimulus response to other organism regulation of postsynaptic membrane potential excitatory postsynaptic potential long-term synaptic potentiation response to growth hormone response to fungicide calcium ion transmembrane transport cellular response to amino acid stimulus cellular response to manganese ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid cellular response to organic cyclic compound cation transmembrane transport
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