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Invitrogen
NMDAR3A/NMDAR3B Monoclonal Antibody (K35/40)
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Product Details
MA1-26500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
K35/40
Immunogen
Fusion protein, corresponding to amino acids 780-914 from the intracellular IIIIV loop of Human NMDAR3A + NMDAR3B.
Conjugate
Form
Liquid
Concentration
1.4 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_795050
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Grin3a is an NMDA (N-methyl-D-aspartate) receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Grin3a is mediated by glycine and may play a role in the development of dendritic spines. Further, Grin3a may play a role in PPP2CB-NMDAR mediated signaling mechanism. Grin3a belongs to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. Grin3a shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in Grin3a suggest that the protein may be involved in the development of synaptic elements by modulating NMDA receptor activity. Diseases associated with GRIN3A include Lingual-Facial-Buccal Dyskinesia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GluN3A; GluN3B; glutamate [NMDA] receptor subunit 3A; glutamate [NMDA] receptor subunit 3B; glutamate receptor; Glutamate receptor chi-1; Glutamate receptor ionotropic, NMDA 3A; Glutamate receptor ionotropic, NMDA 3B; glutamate receptor, ionotropic, N-methyl-D-aspartate 3A; glutamate receptor, ionotropic, N-methyl-D-aspartate 3B; glutamate receptor, ionotropic, NMDA3B; N-methyl-D-aspartate receptor; N-methyl-D-aspartate receptor subtype 3A; N-methyl-D-aspartate receptor subtype 3B; N-methyl-D-aspartate receptor subunit NR3B; NMDA receptor 4; NMDA receptor subunit 3B; NMDA type glutamate receptor subunit NR3B; NMDAR-L; NMDAR-L1; NMDAR3A; NMDAR3B; Nr4
Gene Aliases: 6430537F04; A830097C19Rik; chi-1; GluN3A; GluN3B; GRIN3A; GRIN3B; KIAA1973; mKIAA1973; NMDAR-L; NMDAR3B; NR3; NR3A; NR3B
UniProt ID: (Human) Q8TCU5, (Human) O60391, (Rat) Q9R1M7, (Mouse) A2AIR5, (Mouse) Q91ZU9, (Rat) Q8VHN2
Entrez Gene ID: (Human) 116443, (Human) 116444, (Rat) 191573, (Mouse) 242443, (Mouse) 170483, (Rat) 170796
NMDA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
calcium channel activity
protein binding
glycine binding
identical protein binding
protein phosphatase 2A binding
cation channel activity
neurotransmitter receptor activity
neurotransmitter binding
ionotropic glutamate receptor activity
receptor activity
ion channel activity
transport
ion transport
cation transport
chemical synaptic transmission
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
protein insertion into membrane
regulation of calcium ion transport
cation transmembrane transport
calcium ion transmembrane transport
calcium ion transport
dendrite development
response to ethanol
rhythmic process
prepulse inhibition
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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