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NMT1 Polyclonal Antibody

NMT1 Antibody in Immunocytochemistry (ICC/IF)

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NMT1 Antibody (11546-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using NMT1 antibody 11546-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

NMT1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

NMT1 Antibody in Immunoprecipitation (IP)

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Product Details

11546-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NMT1 Fusion Protein Ag2072 (1-301 aa encoded by BC006569)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MADESETAV KPPAPPLPQM MEGNGNGHEH CSDCENEEDN SYNRGGLSPA NDTGAKKKKK KQKKKKEKGS ETDSAQDQPV KMNSLPAERI QEIQKAIELF SVGQGPAKTM EEASKRSYQF WDTQPVPKLG EVVNTHGPVE PDKDNIRQEP YTLPQGFTWD ALDLGDRGVL KELYTLLNEN YVEDDDNMFR FDYSPEFLLW ALRPPGWLPQ WHCGVRVVSS RKLVGFISAI PANIHIYDTE KKMVEINFLC VHKKLRSKRV APVLIREITR RVHLEGIFQA VYTAGVVLPK PVGTCRYWHR SL (1-301 aa encoded by BC006569)

Target Information

NMT1 is involved with Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1 MIM 139311).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

NMT1 sustains ICAM-1 to modulate adhesion and migration of tumor cells.

Cellular signalling

Wang H,Xu X,Wang Y,Xue X,Guo W,Guo S,Qiu S,Cui J,Qiao Y

Fri Sep 01 00:00:00 UTC 2023

N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression.

Cancer letters

Sun Y,Guan Z,Sheng Q,Duan W,Zhao H,Zhou J,Deng Q,Pei X

Thu Mar 31 00:00:00 UTC 2022

N-myristoyltransferase-1 deficiency blocks myristoylation of LAMTOR1 and inhibits bladder cancer progression.

Cancer letters

Sun Y,Guan Z,Sheng Q,Duan W,Zhao H,Zhou J,Deng Q,Pei X

Thu Mar 31 00:00:00 UTC 2022

Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA.

Brain : a journal of neurology

Božič J,Motaln H,Janež AP,Markič L,Tripathi P,Yamoah A,Aronica E,Lee YB,Heilig R,Fischer R,Thompson AJ,Goswami A,Rogelj B

Mon Apr 18 00:00:00 UTC 2022

NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.

Cell death & disease

Deng L,Gao X,Liu B,He X,Xu J,Qiang J,Wu Q,Liu S

Fri Nov 16 00:00:00 UTC 2018

NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.

Cell death & disease

Deng L,Gao X,Liu B,He X,Xu J,Qiang J,Wu Q,Liu S

Fri Nov 16 00:00:00 UTC 2018

NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.

Cell death & disease

Deng L,Gao X,Liu B,He X,Xu J,Qiang J,Wu Q,Liu S

Fri Nov 16 00:00:00 UTC 2018

NMT1 inhibition modulates breast cancer progression through stress-triggered JNK pathway.

Cell death & disease

Deng L,Gao X,Liu B,He X,Xu J,Qiang J,Wu Q,Liu S

Fri Nov 16 00:00:00 UTC 2018

Tris DBA palladium is highly effective against growth and metastasis of pancreatic cancer in an orthotopic model.

Oncotarget

Díaz B,Ostapoff KT,Toombs JE,Lo J,Bonner MY,Curatolo A,Adsay V,Brekken RA,Arbiser JL

Tue Aug 09 00:00:00 UTC 2016

N-Myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum.

Biochemical and biophysical research communications

Dudek E,Millott R,Liu WX,Beauchamp E,Berthiaume LG,Michalak M

Fri Dec 25 00:00:00 UTC 2015

N-Myristoyltransferase 1 interacts with calnexin at the endoplasmic reticulum.

Biochemical and biophysical research communications

Dudek E,Millott R,Liu WX,Beauchamp E,Berthiaume LG,Michalak M

Fri Dec 25 00:00:00 UTC 2015

Regulation of co- and post-translational myristoylation of proteins during apoptosis: interplay of N-myristoyltransferases and caspases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Perinpanayagam MA,Beauchamp E,Martin DD,Sim JY,Yap MC,Berthiaume LG

Fri Feb 01 00:00:00 UTC 2013

Regulation of co- and post-translational myristoylation of proteins during apoptosis: interplay of N-myristoyltransferases and caspases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Perinpanayagam MA,Beauchamp E,Martin DD,Sim JY,Yap MC,Berthiaume LG

Fri Feb 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: alternative, short form NMT-S; Glycylpeptide N-tetradecanoyltransferase 1; HsNMT1; long form, NMT-L; Myristoyl-CoA:protein N-myristoyltransferase 1; NMT 1; Peptide N-myristoyltransferase 1; Protein-lysine myristoyltransferase NMT1; type I N-myristoyltransferase

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Gene Aliases: AW536594; NMT; NMT1

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UniProt ID: (Human) P30419, (Mouse) O70310, (Rat) Q8K1Q0

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Entrez Gene ID: (Human) 4836, (Mouse) 18107, (Rat) 259274

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Function(s)

glycylpeptide N-tetradecanoyltransferase activity myristoyltransferase activity transferase activity transferase activity, transferring acyl groups

Process(es)

in utero embryonic development N-terminal protein myristoylation N-terminal peptidyl-glycine N-myristoylation biological_process regulation of rhodopsin mediated signaling pathway positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NMT1 Polyclonal Antibody

NMT1 Antibody (11546-1-AP) in ICC/IF

Product Details

11546-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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