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Product Details
PA5-17328
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the carboxy terminus of Nod1 protein
Conjugate
Form
Liquid
Concentration
172 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10980617
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NOD1 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD1 contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and ten tandem leucine-rich repeats (LRRs) in its C-terminus. The CARD is involved in apoptotic signaling, and NOD1 activates caspase-9 and NF-kappa-B. LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: caspase recruitment domain 4; caspase recruitment domain family, member 4; Caspase recruitment domain-containing protein 4; hNod1; mNod1; NLR family, CARD domain containing 1; nucleotide-binding oligomerization domain containing 1; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1; Nucleotide-binding oligomerization domain-containing protein 1
Gene Aliases: C230079P11; CARD4; CLR7.1; F830007N14Rik; NLRC1; NOD1; RGD1562269
UniProt ID: (Human) Q9Y239, (Mouse) Q8BHB0
Entrez Gene ID: (Human) 10392, (Mouse) 107607, (Rat) 500133
activation of MAPK activity
positive regulation of dendritic cell antigen processing and presentation
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
defense response
inflammatory response
signal transduction
JNK cascade
detection of biotic stimulus
detection of bacterium
positive regulation of interleukin-1 beta production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
intracellular signal transduction
interleukin-8 biosynthetic process
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
innate immune response
positive regulation of JNK cascade
defense response to Gram-positive bacterium
positive regulation of nitric-oxide synthase activity
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
positive regulation of ERK1 and ERK2 cascade
nucleotide-binding oligomerization domain containing signaling pathway
cellular response to muramyl dipeptide
positive regulation of NIK/NF-kappaB signaling
positive regulation of xenophagy
immune system process
positive regulation of cell death
positive regulation of stress-activated MAPK cascade
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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