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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • NOD2 Antibodies

          Bioss

          NOD2 Polyclonal Antibody

          View all (14) NOD2 antibodies

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          Cite NOD2 Polyclonal Antibody

          • Antibody Testing Data (1)
          NOD2 Antibody in Western Blot (WB)
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          NOD2 Antibody in Western Blot (WB)
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          NOD2 Antibody (BS-7084R) in WB

          A549 cell lysates probed with CARD15/NOD2 Polyclonal Antibody, Unconjugated (bs-7084R) at 1:300 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          NOD2 Antibody in Western Blot (WB)

          Product Details

          BS-7084R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:300
          -

          Flow Cytometry (Flow)

          1:20-1:100
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human CARD15, amino acids 251-350.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NOD 2; NOD-2; NOD-like receptor C2; NOD2 protein; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2

          View more View less

          Gene Aliases: ACUG; BLAU; CARD15; CD; CLR16.3; F830032C23Rik; IBD1; NLRC2; NOD2; NOD2B; PSORAS1

          View more View less

          UniProt ID: (Human) Q9HC29

          View more View less

          Entrez Gene ID: (Human) 64127, (Rat) 291912, (Mouse) 257632

          View more View less

          Function(s)
          actin binding protein binding ATP binding enzyme binding protein kinase binding Hsp70 protein binding muramyl dipeptide binding peptidoglycan binding CARD domain binding Hsp90 protein binding nucleotide binding endodeoxyribonuclease activity, producing 5'-phosphomonoesters
          Process(es)
          innate immune response in mucosa activation of immune response cytokine production involved in immune response immunoglobulin production involved in immunoglobulin mediated immune response positive regulation of dendritic cell antigen processing and presentation negative regulation of T cell mediated immunity positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria response to nutrient positive regulation of cell proliferation detection of bacterium maintenance of gastrointestinal epithelium positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to muramyl dipeptide response to lipopolysaccharide detection of muramyl dipeptide negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-2 production negative regulation of tumor necrosis factor production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade negative regulation of toll-like receptor 2 signaling pathway activation of MAPK activity involved in innate immune response intracellular signal transduction defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity negative regulation of growth of symbiont in host innate immune response positive regulation of innate immune response positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of epithelial cell proliferation positive regulation of interleukin-1 beta secretion regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis defense response to Gram-positive bacterium positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase biosynthetic process positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to peptidoglycan cellular response to muramyl dipeptide cellular response to organic cyclic compound macrophage inflammatory protein-1 alpha production regulation of neutrophil chemotaxis negative regulation of macrophage apoptotic process positive regulation of prostaglandin-E synthase activity cytokine secretion involved in immune response immune system process defense response inflammatory response signal transduction detection of biotic stimulus protein oligomerization positive regulation of cytokine production involved in inflammatory response activation of MAPK activity JNK cascade positive regulation of interleukin-8 production positive regulation of gamma-delta T cell activation nucleotide-binding oligomerization domain containing signaling pathway positive regulation of NIK/NF-kappaB signaling
          It has to be done as per old AB suggested Products section.
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