Invitrogen

NOD2 Monoclonal Antibody (2D9)

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View all (14) NOD2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA1-16611

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:500
-

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent
-

Immunocytochemistry (ICC/IF)

1:50-1:500
View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-Dependent
-

Immunoprecipitation (IP)

1:10-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2D9

Immunogen

Recombinant human NOD2 protein corresponding to residues 28-301.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568643

Product Specific Information

The target sequence has 92% sequence homology with primate.

Target Information

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: caspase recruitment domain family, member 15; caspase recruitment domain protein 15; Caspase recruitment domain-containing protein 15; Inflammatory bowel disease protein 1; NLR family, CARD domain containing 2; NOD 2; NOD-2; NOD-like receptor C2; NOD2 protein; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain containing 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2; Nucleotide-binding oligomerization domain-containing protein 2

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Gene Aliases: ACUG; BLAU; CARD15; CD; CLR16.3; F830032C23Rik; IBD1; NLRC2; NOD2; NOD2B; PSORAS1

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UniProt ID: (Human) Q9HC29

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Entrez Gene ID: (Human) 64127, (Mouse) 257632

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Function(s)
actin binding protein binding ATP binding enzyme binding protein kinase binding Hsp70 protein binding muramyl dipeptide binding peptidoglycan binding CARD domain binding Hsp90 protein binding nucleotide binding endodeoxyribonuclease activity, producing 5'-phosphomonoesters
Process(es)
innate immune response in mucosa activation of immune response cytokine production involved in immune response cytokine secretion involved in immune response immune system process immunoglobulin production involved in immunoglobulin mediated immune response positive regulation of dendritic cell antigen processing and presentation negative regulation of T cell mediated immunity positive regulation of dendritic cell cytokine production positive regulation of type 2 immune response negative regulation of inflammatory response to antigenic stimulus positive regulation of humoral immune response mediated by circulating immunoglobulin defense response inflammatory response positive regulation of antibacterial peptide biosynthetic process positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria signal transduction positive regulation of cell proliferation detection of biotic stimulus detection of bacterium maintenance of gastrointestinal epithelium positive regulation of protein ubiquitination negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to muramyl dipeptide response to lipopolysaccharide detection of muramyl dipeptide negative regulation of interferon-gamma production negative regulation of interleukin-12 production negative regulation of interleukin-18 production negative regulation of interleukin-2 production negative regulation of tumor necrosis factor production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production positive regulation of stress-activated MAPK cascade negative regulation of toll-like receptor 2 signaling pathway activation of MAPK activity involved in innate immune response intracellular signal transduction defense response to bacterium regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling response to exogenous dsRNA positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity negative regulation of growth of symbiont in host innate immune response positive regulation of innate immune response positive regulation of Notch signaling pathway positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of epithelial cell proliferation positive regulation of interleukin-1 beta secretion regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of phagocytosis defense response to Gram-positive bacterium positive regulation of B cell activation positive regulation of NF-kappaB transcription factor activity protein oligomerization positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase biosynthetic process positive regulation of prostaglandin-endoperoxide synthase activity positive regulation of ERK1 and ERK2 cascade nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to peptidoglycan cellular response to muramyl dipeptide macrophage inflammatory protein-1 alpha production regulation of neutrophil chemotaxis positive regulation of cytokine production involved in inflammatory response negative regulation of macrophage apoptotic process positive regulation of prostaglandin-E synthase activity activation of MAPK activity JNK cascade positive regulation of interleukin-8 production positive regulation of gamma-delta T cell activation nucleotide-binding oligomerization domain containing signaling pathway positive regulation of NIK/NF-kappaB signaling
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