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Proteintech
NOL12 Polyclonal Antibody
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Product Details
15456-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NOL12 Fusion Protein Ag7723 (1-213 aa encoded by BC002808)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGRNKKKKR DGDDRRPRLV LSFDEEKRRE YLTGFHKRKV ERKKAAIEEI KQRLKEEQRK LREERHQEYL KMLAEREEAL EEADELDRLV TAKTESVQYD HPNHTVTVTT ISDLDLSGAR LLGLTPPEGG AGDRSEEEAS STEKPTKALP RKSRDPLLSQ RISSLTASLH AHSRKKVKRK HPRRAQDSKK PPRAPRTSKA QRRRLTGKAR HSGE (1-213 aa encoded by BC002808)
Target Information
Nop25 is a nucleolar protein predominantly involved in the architecture and function of the nucleolus, which is the cellular hub for ribosomal RNA (rRNA) synthesis and ribosome assembly. It is identified as a putative RNA-binding protein and plays a crucial role in rRNA transcription. Nop25 has been characterized through molecular cloning, showing its ability to bind single-stranded nucleic acids directly. Experimental studies, such as those involving mouse embryogenesis, have utilized techniques like RT-PCR to analyze Nop25's gene expression across developmental stages. Moreover, research on the protein's structure has unveiled its nuclear and nucleolar targeting sequences, vital for its localization to the nucleolus. Treatment of cells with RNase A has illustrated the dissociation of Nop25 from the nucleolus, further highlighting its RNA-binding capabilities. This protein's functional importance is underscored by its role in maintaining nucleolar architecture, as demonstrated by experiments where overexpression of Nop25's N-terminal amino acids disrupted nucleolar integrity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 25 kDa nucleolar protein; Nucleolar protein 12; Nucleolar protein of 25 kDa; nucleolar protein, 25 kDa
Gene Aliases: C78541; dJ37E16.7; NOL12; Nop25; RGD1305327
UniProt ID: (Human) Q9UGY1, (Mouse) Q8BG17, (Rat) Q5D1Z3
Entrez Gene ID: (Human) 79159, (Mouse) 97961, (Rat) 362955
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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