Bioss

NOR1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-11903R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

Assay-dependent
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NOR1, amino acids 521-626.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Neuron-derived orphan receptor 1/2; Nuclear hormone receptor NOR-1; Nuclear hormone receptor NOR-1/NOR-2; Nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3; Orphan nuclear receptor TEC; TEC receptor; Translocated in extraskeletal chondrosarcoma

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Gene Aliases: AI573420; CHN; CSMF; MINOR; NOR-1; NOR-2; NOR1; NR4A3; TEC

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UniProt ID: (Human) Q92570, (Rat) P51179, (Mouse) Q9QZB6

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Entrez Gene ID: (Human) 8013, (Rat) 58853, (Mouse) 18124

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator binding DNA binding steroid hormone receptor activity thyroid hormone receptor activity protein binding zinc ion binding protein kinase binding histone acetyltransferase binding glucocorticoid receptor binding protein homodimerization activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding sequence-specific DNA binding
Process(es)
mesoderm formation transcription, DNA-templated transcription from RNA polymerase II promoter axon guidance hippocampus development intracellular receptor signaling pathway adult behavior organ regeneration inner ear morphogenesis response to hydrogen peroxide negative regulation of apoptotic process steroid hormone mediated signaling pathway response to peptide hormone negative regulation of neuron apoptotic process positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter semicircular canal morphogenesis neuromuscular process controlling balance vestibular reflex positive regulation of leukocyte apoptotic process negative regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter gastrulation biological_process pyruvate oxidation positive regulation of cardiac muscle hypertrophy positive regulation of glucose transport positive regulation of mast cell cytokine production common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway mast cell degranulation cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of fatty acid oxidation regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation negative regulation of hydrogen peroxide-induced neuron death positive regulation of feeding behavior regulation of energy homeostasis
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