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Product Details
27979-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NOSIP Fusion Protein Ag27569 (1-301 aa encoded by BC010077)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTRHGKNCT AGAVYTYHEK KKDTAASGYG TQNIRLSRDA VKDFDCCCLS LQPCHDPVVT PDGYLYEREA ILEYILHQKK EIARQMKAYE KQRGTRREEQ KELQRAASQD HVRGFLEKES AIVSRPLNPF TAKALSGTSP DDVQPGPSVG PPSKDKDKVL PSFWIPSLTP EAKATKLEKP SRTVTCPMSG KPLRMSDLTP VHFTPLDSSV DRVGLITRSE RYVCAVTRDS LSNATPCAVL RPSGAVVTLE CVEKLIRKDM VDPVTGDKLT DRDIIVLQRG GTGFAGSGVK LQAEKSRPVM QA (1-301 aa encoded by BC010077)
Target Information
NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1. 2, Nav1. 3, Nav1. 5, Nav1. 7, Nav1. 8, Kv1. 3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase NOSIP; eNOS-interacting protein; Nitric oxide synthase-interacting protein; RING-type E3 ubiquitin transferase NOSIP
Gene Aliases: CGI-25; NOSIP
UniProt ID: (Human) Q9Y314
Entrez Gene ID: (Human) 51070
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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