Proteintech

NOTCH2 Polyclonal Antibody

FIGURE: 1 / 1

NOTCH2 Antibody (28580-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with 28580-1-AP (NOTCH2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

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Product Details

28580-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NOTCH2 fusion protein Ag29413

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

333 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

[DTX2 overexpression promotes migration and invasion of colorectal cancer cells through the Notch2/Akt axis].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

Ma Z,Zhao X,Zhang X,Xu G,Liu F

Mon Mar 20 00:00:00 UTC 2023

Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.

Cancer letters

Yan R,Dai W,Wu R,Huang H,Shu M

Sat May 28 00:00:00 UTC 2022

A comprehensive role evaluation and mechanism exploration of POGLUT2 in pan-cancer.

Frontiers in oncology

Xu X,Xie G,Xie M,Liu Q

Wed Sep 28 00:00:00 UTC 2022

Evaluation of NOTCH family genes' expression and prognostic value in prostate cancer.

Translational andrology and urology

Qing Y,Wang Y,Hu C,Zhang H,Huang Y,Zhang Z,Ma T,Zhang S,Li K

Sun May 01 00:00:00 UTC 2022

APEX2-Mediated Proximity Labeling Resolves the DDIT4-Interacting Proteome.

International journal of molecular sciences

Naki M,Gourdomichali O,Zonke K,Kattan FG,Makridakis M,Kontostathi G,Vlahou A,Doxakis E

Fri May 06 00:00:00 UTC 2022

SLC6A8 is involved in the progression of non-small cell lung cancer through the Notch signaling pathway.

Annals of translational medicine

Feng Y,Guo X,Tang H

Mon Feb 01 00:00:00 UTC 2021

GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.

Life sciences

Wang W,Sun R,Zeng L,Chen Y,Zhang N,Cao S,Deng S,Meng X,Yang S

Thu Jul 01 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: Neurogenic locus notch homolog protein 2; Notch 2; Notch homolog 2

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Gene Aliases: AGS2; HJCYS; hN2; NOTCH2

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UniProt ID: (Human) Q04721

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Entrez Gene ID: (Human) 4853

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Function(s)

receptor activity calcium ion binding protein binding transcription factor activity, ligand-activated RNA polymerase II transcription factor binding

Process(es)

cell fate determination marginal zone B cell differentiation pulmonary valve morphogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter apoptotic process cell cycle arrest Notch signaling pathway multicellular organism development nervous system development negative regulation of cell proliferation organ morphogenesis cell growth stem cell population maintenance hemopoiesis intracellular receptor signaling pathway tissue regeneration negative regulation of apoptotic process positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process atrial septum morphogenesis Notch signaling involved in heart development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NOTCH2 Polyclonal Antibody

NOTCH2 Antibody (28580-1-AP) in WB

Product Details

28580-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunoprecipitation (IP)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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