Invitrogen

NOTCH2 (Cleaved Ala1734) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-37433

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 1734-1800 of human Notch 2
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554057

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 85 and 110 kDa.

Purity is >95% by SDS-PAGE.

Target Information

The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Motch B; Neurogenic locus notch homolog protein 2; Notch 2; Notch gene homolog 2; Notch homolog 2

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Gene Aliases: AGS2; AI853703; HJCYS; hN2; N2; NOTCH2

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UniProt ID: (Human) Q04721, (Mouse) O35516

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Entrez Gene ID: (Human) 4853, (Mouse) 18129, (Rat) 29492

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Function(s)
receptor activity calcium ion binding protein binding transcription factor activity, ligand-activated RNA polymerase II transcription factor binding enzyme binding NF-kappaB binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development cell fate determination liver development placenta development heart looping morphogenesis of an epithelial sheet inflammatory response to antigenic stimulus pulmonary valve morphogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter humoral immune response cell cycle arrest Notch signaling pathway multicellular organism development determination of left/right symmetry positive regulation of cell proliferation negative regulation of cell proliferation organ morphogenesis cell growth cell differentiation embryonic limb morphogenesis positive regulation of BMP signaling pathway multicellular organism growth intrahepatic bile duct development wound healing defense response to bacterium myeloid dendritic cell differentiation positive regulation of apoptotic process positive regulation of osteoclast differentiation positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process atrial septum morphogenesis placenta blood vessel development ciliary body morphogenesis left/right axis specification hepatocyte proliferation liver morphogenesis interleukin-4 secretion cholangiocyte proliferation tissue regeneration marginal zone B cell differentiation transcription initiation from RNA polymerase II promoter apoptotic process nervous system development stem cell population maintenance hemopoiesis intracellular receptor signaling pathway negative regulation of apoptotic process Notch signaling involved in heart development
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