Proteintech

NOXA2/p67phox Polyclonal Antibody

NOXA2/p67phox Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

NOXA2/p67phox Antibody (15551-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 15551-1-AP ( NOXA2/p67phox antibody at dilution of 1:50 (under 40x lens).

NOXA2/p67phox Antibody in Western Blot (WB)

Product Image Gallery

Product Details

15551-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NOXA2/p67phox Fusion Protein Ag7909 (178-526 aa encoded by BC001606)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: PVGRLFRPN ERQVAQLAKK DYLGKATVVA SVVDQDSFSG FAPLQPQAAE PPPRPKTPEI FRALEGEAHR VLFGFVPETK EELQVMPGNI VFVLKKGNDN WATVMFNGQK GLVPCNYLEP VELRIHPQQQ PQEESSPQSD IPAPPSSKAP GRPQLSPGQK QKEEPKEVKL SVPMPYTLKV HYKYTVVMKT QPGLPYSQVR DMVSKKLELR LEQTKLSYRP RDSNELVPLS EDSMKDAWGQ VKNYCLTLWC ENTVGDQGFP DEPKESEKAD ANNQTTEPQL KKGSQVEALF SYEATQPEDL EFQEGDIILV LSKVNEEWLE GECKGKVGIF PKVFVEDCAT TDLESTRREV (178-526 aa encoded by BC001606)

Target Information

NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Defects in NCF2 are a cause of chronic granulomatous disease autosomal recessive cytochrome-b-positive type 2 (CGD2). Chronic granulomatous disease is a genetically heterogeneous disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus.

Andrology

Sun T,Xu W,Wang J,Wang T,Wang S,Liu K,Liu J

Wed Feb 01 00:00:00 UTC 2023

Novel Diagnostic Biomarkers Related to Oxidative Stress and Macrophage Ferroptosis in Atherosclerosis.

Oxidative medicine and cellular longevity

Li M,Xin S,Gu R,Zheng L,Hu J,Zhang R,Dong H

Tue Aug 30 00:00:00 UTC 2022

Novel macrophage-related gene prognostic index for glioblastoma associated with M2 macrophages and T cell dysfunction.

Frontiers in immunology

Ji H,Liu Z,Wang F,Sun H,Wang N,Liu Y,Hu S,You C

Mon Oct 03 00:00:00 UTC 2022

Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk.

British journal of pharmacology

Zhou Y,Gao C,Vong CT,Tao H,Li H,Wang S,Wang Y

Sun May 01 00:00:00 UTC 2022

Rhein regulates redox-mediated activation of NLRP3 inflammasomes in intestinal inflammation through macrophage-activated crosstalk.

British journal of pharmacology

Zhou Y,Gao C,Vong CT,Tao H,Li H,Wang S,Wang Y

Sun May 01 00:00:00 UTC 2022

Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.

Stem cell research & therapy

Wang Y,Zhang Y,Chen K,Liu J,Wu D,Cheng Y,Wang H,Li Y

Sat Aug 13 00:00:00 UTC 2022

Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.

Oxidative medicine and cellular longevity

Zhang M,Luo C,Lin D,Cui K,Chen Z,Liu J

Fri Nov 12 00:00:00 UTC 2021

Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.

Journal of hazardous materials

Xiaoli F,Yaqing Z,Ruhui L,Xuan L,Aijie C,Yanli Z,Chen H,Lili C,Longquan S

Sun Aug 15 00:00:00 UTC 2021

Oxidation of Reduced Graphene Oxide via Cellular Redox Signaling Modulates Actin-Mediated Neurotransmission.

ACS nano

Kang Y,Liu J,Yin S,Jiang Y,Feng X,Wu J,Zhang Y,Chen A,Zhang Y,Shao L

Tue Mar 24 00:00:00 UTC 2020

Glutamine Supplementation Prevents Chronic Stress-Induced Mild Cognitive Impairment.

Nutrients

Baek JH,Jung S,Son H,Kang JS,Kim HJ

Thu Mar 26 00:00:00 UTC 2020

Testosterone preserves endothelial function through regulation of S1P1/Akt/FOXO3a signalling pathway in the rat corpus cavernosum.

Andrologia

Cui K,Li R,Liu K,Wang T,Liu J,Rao K

Fri Feb 01 00:00:00 UTC 2019

Testosterone preserves endothelial function through regulation of S1P1/Akt/FOXO3a signalling pathway in the rat corpus cavernosum.

Andrologia

Cui K,Li R,Liu K,Wang T,Liu J,Rao K

Fri Feb 01 00:00:00 UTC 2019

Chronic gestational hypoxia accelerates ovarian aging and lowers ovarian reserve in next-generation adult rats.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Aiken CE,Tarry-Adkins JL,Spiroski AM,Nuzzo AM,Ashmore TJ,Rolfo A,Sutherland MJ,Camm EJ,Giussani DA,Ozanne SE

Sat Jun 01 00:00:00 UTC 2019

Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.

The Journal of physiology

Aiken CE,Tarry-Adkins JL,Spiroski AM,Nuzzo AM,Ashmore TJ,Rolfo A,Sutherland MJ,Camm EJ,Giussani DA,Ozanne SE

Wed May 01 00:00:00 UTC 2019

Sorafenib promotes sensory conduction function recovery via miR-142-3p/AC9/cAMP axis post dorsal column injury.

Neuropharmacology

Wang T,Li B,Wang Z,Wang X,Xia Z,Ning G,Wang X,Zhang Y,Cui L,Yu M,Zhang L,Zhang Z,Yuan W,Guo X,Yuan X,Feng S,Chen X

Mon Apr 01 00:00:00 UTC 2019

PEITC promotes neurite growth in primary sensory neurons via the miR-17-5p/STAT3/GAP-43 axis.

Journal of drug targeting

Wang Z,Yuan W,Li B,Chen X,Zhang Y,Chen C,Yu M,Xiu Y,Li W,Cao J,Wang X,Tao W,Guo X,Feng S,Wang T

Tue Jan 01 00:00:00 UTC 2019

Serum response factor (SRF) promotes ROS generation and hepatic stellate cell activation by epigenetically stimulating NCF1/2 transcription.

Redox biology

Kong M,Chen X,Lv F,Ren H,Fan Z,Qin H,Yu L,Shi X,Xu Y

Sun Sep 01 00:00:00 UTC 2019

Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.

Asian journal of andrology

Cui K,Tang Z,Li CC,Wang T,Rao K,Wang SG,Liu JH,Chen Z

Tue May 14 00:00:00 UTC 2019

Lipoxin A4 improves erectile dysfunction in rats with type I diabetes by inhibiting oxidative stress and corporal fibrosis.

Asian journal of andrology

Cui K,Tang Z,Li CC,Wang T,Rao K,Wang SG,Liu JH,Chen Z

Tue May 14 00:00:00 UTC 2019

Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats.

Disease models & mechanisms

Tarry-Adkins JL,Fernandez-Twinn DS,Chen JH,Hargreaves IP,Neergheen V,Aiken CE,Ozanne SE

Sat Oct 01 00:00:00 UTC 2016

Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats.

Disease models & mechanisms

Tarry-Adkins JL,Fernandez-Twinn DS,Chen JH,Hargreaves IP,Neergheen V,Aiken CE,Ozanne SE

Sat Oct 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NADPH oxidase subunit (67 kD); NADPH oxidase subunit (67kDa); NCF-2; ncf2; ncf2 {ECO:0000312|EMBL:FAA00361.1}; Neutrophil cytosol factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; p67-phox

View more View less

Gene Aliases: NCF-2; NCF2; NOXA2; P67-PHOX; P67PHOX

View more View less

UniProt ID: (Human) P19878, (Mouse) O70145

View more View less

Entrez Gene ID: (Human) 4688, (Mouse) 17970, (Rat) 364018

View more View less

Function(s)

protein binding protein C-terminus binding electron carrier activity superoxide-generating NADPH oxidase activity Rac GTPase binding molecular_function

Process(es)

NADP catabolic process superoxide metabolic process response to glucose response to organic cyclic compound response to lipopolysaccharide cellular response to hormone stimulus superoxide anion generation positive regulation of neuron apoptotic process positive regulation of blood pressure aging response to activity response to progesterone response to lipid response to laminar fluid shear stress response to drug response to hyperoxia antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent cellular defense response innate immune response cell redox homeostasis respiratory burst vascular endothelial growth factor receptor signaling pathway oxidation-reduction process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

NOXA2/p67phox Polyclonal Antibody

NOXA2/p67phox Antibody (15551-1-AP) in IHC (P)

Product Details

15551-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!