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This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle.
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Protein Aliases: AAP-S; Cytosol alanyl aminopeptidase; metalloproteinase MP100; PSA; Puromycin-sensitive aminopeptidase
Gene Aliases: AAP-S; MP100; NPEPPS; PSA
UniProt ID: (Human) P55786
Entrez Gene ID: (Human) 9520, (Rat) 50558
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