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Proteintech
NPR2 Polyclonal Antibody
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Product Details
55113-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M sodium bicarbonate/0.1M glycine, pH 7.3, with 50% glycerol, 0.1M glycine
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The antibody is specific to NPR2.
Target Information
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ANP-B; ANPR-B; atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase 2B; Guanylate cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); Nppb receptor; NPR-B
Gene Aliases: AMDM; ANPb; ANPRB; cn; ECDM; GC-B; GC-B2; GC-B3; GUC2B; GUCY2B; mNPR-B; NPR2; NPRB; NPRBi; pwe; SNSK
UniProt ID: (Human) P20594, (Mouse) Q6VVW5
Entrez Gene ID: (Human) 4882, (Mouse) 230103
adenylate cyclase activity
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
natriuretic peptide receptor activity
peptide hormone binding
hormone binding
identical protein binding
nucleotide binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
ossification
cGMP biosynthetic process
protein phosphorylation
signal transduction
receptor guanylyl cyclase signaling pathway
cyclic nucleotide biosynthetic process
intracellular signal transduction
single organism reproductive process
negative regulation of meiotic cell cycle
bone development
negative regulation of oocyte maturation
regulation of blood pressure
cellular response to granulocyte macrophage colony-stimulating factor stimulus
regulation of cardiac conduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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