Proteintech

NPTX2 Polyclonal Antibody

NPTX2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

NPTX2 Antibody (10889-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 10889-1-AP (NPTX2 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

NPTX2 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10889-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

Assay-dependent

View 7 publications 7 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NPTX2 Fusion Protein Ag1326 (1-350 aa encoded by BC009924)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLALLAASV ALAVAAGAQD SPAPGSRFVC TALPPEAVHA GCPLPAMPMQ GGAQSPEEEL RAAVLQLRET VVQQKETLGA QREAIRELTG KLARCEGLAG GKARGAGATG KDTMGDLPRD PGHVVEQLSR SLQTLKDRLE SLEHQLRANV SNAGLPGDFR EVLQQRLGEL ERQLLRKVAE LEDEKSLLHN ETSAHRQKTE STLNALLQRV TELERGNSAF KSPDAFKVSL PLRTNYLYGK IKKTLPELYA FTICLWLRSS ASPGIGTPFS YAVPGQANEI VLIEWGNNPI ELLINDKVAQ LPLFVSDGKW HHICVTWTTR DGMWEAFQDG EKLGTGENLA PWHPIKPGGV L (1-350 aa encoded by BC009924)

Target Information

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson’s disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Deep proteomics identifies shared molecular pathway alterations in synapses of patients with schizophrenia and bipolar disorder and mouse model.

Cell reports

Aryal S,Bonanno K,Song B,Mani DR,Keshishian H,Carr SA,Sheng M,Dejanovic B

Tue May 30 00:00:00 UTC 2023

NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL.

The Journal of investigative dermatology

Kang T,Zhang C,Lei H,Luo R,Liu M,Wang S,Zhang X,Duan Q,Xiao S,Zheng Y

Thu Jun 01 00:00:00 UTC 2023

NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL.

The Journal of investigative dermatology

Kang T,Zhang C,Lei H,Luo R,Liu M,Wang S,Zhang X,Duan Q,Xiao S,Zheng Y

Thu Jun 01 00:00:00 UTC 2023

NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL.

The Journal of investigative dermatology

Kang T,Zhang C,Lei H,Luo R,Liu M,Wang S,Zhang X,Duan Q,Xiao S,Zheng Y

Thu Jun 01 00:00:00 UTC 2023

Reduced synaptic proteins and SNARE complexes in Down syndrome with Alzheimer's disease and the Dp16 mouse Down syndrome model: Impact of APP gene dose.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Chen XQ,Zuo X,Becker A,Head E,Mobley WC

Mon May 01 00:00:00 UTC 2023

Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation.

Developmental neuroscience

Nugent M,St Pierre M,Brown A,Nassar S,Parmar P,Kitase Y,Duck SA,Pinto C,Jantzie L,Fung C,Chavez-Valdez R

Sun Oct 15 00:00:00 UTC 2023

Intrauterine Growth Restriction Disrupts the Postnatal Critical Period of Synaptic Plasticity in the Mouse Dorsal Hippocampus in a Model of Hypertensive Disease of Pregnancy.

Developmental neuroscience

St Pierre M,Rastogi N,Brown A,Parmar P,Lechner C,Fung C,Chavez-Valdez R

Wed Sep 14 00:00:00 UTC 2022

Intrauterine Growth Restriction Disrupts the Postnatal Critical Period of Synaptic Plasticity in the Mouse Dorsal Hippocampus in a Model of Hypertensive Disease of Pregnancy.

Developmental neuroscience

St Pierre M,Rastogi N,Brown A,Parmar P,Lechner C,Fung C,Chavez-Valdez R

Wed Sep 14 00:00:00 UTC 2022

Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer.

Journal of Cancer

Su Y,Huang Q,Lu L,Qu H,Wang D,Qiu J,Li W,Lin M,Liu H,Wang Z,Yang X

Tue Jan 25 00:00:00 UTC 2022

Promoter Methylation-Mediated NPTX2 Silencing Promotes Tumor Growth in Human Prostate Cancer.

Journal of Cancer

Su Y,Huang Q,Lu L,Qu H,Wang D,Qiu J,Li W,Lin M,Liu H,Wang Z,Yang X

Tue Jan 25 00:00:00 UTC 2022

Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease.

Journal of neurochemistry

Sathe G,Albert M,Darrow J,Saito A,Troncoso J,Pandey A,Moghekar A

Mon Mar 01 00:00:00 UTC 2021

Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2).

Bioengineered

Pei L,Lv X,Jia G,Tan X,Li M,Zhang A

Wed Dec 01 00:00:00 UTC 2021

Identification of Neuronal Pentraxins as Synaptic Binding Partners of C1q and the Involvement of NP1 in Synaptic Pruning in Adult Mice.

Frontiers in immunology

Kovács RÁ,Vadászi H,Bulyáki É,Török G,Tóth V,Mátyás D,Kun J,Hunyadi-Gulyás É,Fedor FZ,Csincsi Á,Medzihradszky K,Homolya L,Juhász G,Kékesi KA,Józsi M,Györffy BA,Kardos J

Wed Jun 16 00:00:00 UTC 2021

NPTX2 promotes colorectal cancer growth and liver metastasis by the activation of the canonical Wnt/β-catenin pathway via FZD6.

Cell death & disease

Xu C,Tian G,Jiang C,Xue H,Kuerbanjiang M,Sun L,Gu L,Zhou H,Liu Y,Zhang Z,Xu Q

Mon Mar 04 00:00:00 UTC 2019

Profiling the Gene Expression and DNA Methylation in the Mouse Brain after Ischemic Preconditioning.

Neuroscience

Cai M,Zhu Y,Li Z,Josephs-Spaulding J,Zhou Y,Hu Y,Chen H,Liu Y,He W,Zhang J

Wed May 15 00:00:00 UTC 2019

NPTX2 is a key component in the regulation of anxiety.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Chang S,Bok P,Tsai CY,Sun CP,Liu H,Deussing JM,Huang GJ

Wed Aug 01 00:00:00 UTC 2018

NPTX2 is a key component in the regulation of anxiety.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Chang S,Bok P,Tsai CY,Sun CP,Liu H,Deussing JM,Huang GJ

Wed Aug 01 00:00:00 UTC 2018

NPTX2 is a key component in the regulation of anxiety.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Chang S,Bok P,Tsai CY,Sun CP,Liu H,Deussing JM,Huang GJ

Wed Aug 01 00:00:00 UTC 2018

Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers.

Digestive diseases and sciences

Zhang L,Gao J,Li Z,Gong Y

Mon Oct 01 00:00:00 UTC 2012

Neuronal pentraxin II (NPTX2) is frequently down-regulated by promoter hypermethylation in pancreatic cancers.

Digestive diseases and sciences

Zhang L,Gao J,Li Z,Gong Y

Mon Oct 01 00:00:00 UTC 2012

The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.

Molecular biology reports

Zhang L,Gao J,Li L,Li Z,Du Y,Gong Y

Tue Nov 01 00:00:00 UTC 2011

The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.

Molecular biology reports

Zhang L,Gao J,Li L,Li Z,Du Y,Gong Y

Tue Nov 01 00:00:00 UTC 2011

The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.

Molecular biology reports

Zhang L,Gao J,Li L,Li Z,Du Y,Gong Y

Tue Nov 01 00:00:00 UTC 2011

The neuronal pentraxin II gene (NPTX2) inhibit proliferation and invasion of pancreatic cancer cells in vitro.

Molecular biology reports

Zhang L,Gao J,Li L,Li Z,Du Y,Gong Y

Tue Nov 01 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: apexin; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; Neuronal pentraxin II; Neuronal pentraxin-2; NP-II; NP2

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Gene Aliases: NARP; NP-II; NP2; NPTX2

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UniProt ID: (Human) P47972, (Mouse) O70340

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Entrez Gene ID: (Human) 4885, (Rat) 288475, (Mouse) 53324

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Function(s)

molecular_function carbohydrate binding metal ion binding

Process(es)

associative learning chemical synaptic transmission

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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NPTX2 Polyclonal Antibody

NPTX2 Antibody (10889-1-AP) in IHC (P)

Product Details

10889-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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