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Invitrogen
NPY Polyclonal Antibody
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NPY Antibody (PA5-19568) in IHC (P)
Immunohistochemical (formalin-fixed, paraffin-embedded) staining of Human cerebral cortex tissue using Product # PA5-19568, anti-Neuropeptide Y antibody. Primary antibody was used at a concentration of 1 µg/mL and exposed for 8 mins at room temp. The sample was pretreated using heat mediated antigen retrieval with Sodium Citrate Buffer (pH6/20mins). The detection method was a HRP conjugated polymer, DAB chr... View More
Product Details
PA5-19568
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 1 to the C-terminus of Pig Neuropeptide Y.
Conjugate
Form
Liquid
Concentration
0.9 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10987237
Product Specific Information
Heat mediated antigen retrieval recommended prior to tissue staining.
This antibody is predicted to react with sheep, rabbit, chicken, guinea pig, cow, pigeon, pig, zebrafish and rhesus monkey based on sequence homology.
Target Information
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase, regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Neuropeptide-Y; OTTHUMP00000201947; prepro-neuropeptide Y; Pro-neuropeptide Y
Gene Aliases: NPY; PYY4
UniProt ID: (Human) P01303
Entrez Gene ID: (Human) 4852
calcium ion transport
movement of cell or subcellular component
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
chemical synaptic transmission
digestion
behavior
feeding behavior
blood circulation
regulation of blood pressure
cell proliferation
adult feeding behavior
central nervous system neuron development
cerebral cortex development
neuron projection development
regulation of appetite
positive regulation of appetite
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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