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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • LXR alpha Antibodies

          Proteintech

          NR1H3 Polyclonal Antibody

          79 References
          View all (21) LXR alpha antibodies

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          Datasheet
          Protocols
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          Datasheet
          Protocols
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          Cite NR1H3 Polyclonal Antibody

          • Antibody Testing Data (3)
          NR1H3 Antibody in Western Blot (WB)
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          NR1H3 Antibody in Western Blot (WB)
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          FIGURE: 1 / 3

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          NR1H3 Antibody (14351-1-AP) in WB

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          NR1H3 Antibody in Western Blot (WB)
          NR1H3 Antibody in Western Blot (WB)
          NR1H3 Antibody in Western Blot (WB)

          Product Details

          14351-1-AP

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:3,000
          View 72 publications 72 publications

          Immunohistochemistry (IHC)

          -
          View 3 publications 3 publications

          Immunocytochemistry (ICC/IF)

          Assay-dependent
          View 2 publications 2 publications

          Immunoprecipitation (IP)

          -
          View 1 publication 1 publication

          ChIP assay (ChIP)

          -
          View 1 publication 1 publication
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          NR1H3 Fusion Protein Ag5697 (104-402 aa encoded by BC041172)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.19 mg/mL

          Purification

          Antigen affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Wet ice (domestic); Dry ice (international)

          Product Specific Information

          Immunogen sequence: KCQECRLRK CRQAGMREEC VLSEEQIRLK KLKRQEEEQA HATSLPPRAS SPPQILPQLS PEQLGMIEKL VAAQQQCNRR SFSDRLRVTP WPMAPDPHSR EARQQRFAHF TELAIVSVQE IVDFAKQLPG FLQLSREDQI ALLKTSAIEV MLLETSRRYN PGSESITFLK DFSYNREDFA KAGLQVEFIN PIFEFSRAMN ELQLNDAEFA LLIAISIFSA DRPNVQDQLQ VERLQHTYVE ALHAYVSIHH PHDRLMFPRM LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE (104-402 aa encoded by BC041172)

          Target Information

          NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: liver X nuclear receptor alpha variant 1; Liver X receptor alpha; LXR alpha; LXRb; NER; NERI; NR1H2; nuclear orphan receptor LXR-alpha; Nuclear receptor subfamily 1 group H member 3; nuclear receptor subfamily 1, group H, member 3; Oxysterols receptor LXR-alpha; RLD-1; ubiquitously-expressed nuclear receptor 1

          View more View less

          Gene Aliases: AU018371; LXR; LXR-a; LXRA; LXRalpha; NR1H3; RLD-1; RLD1; Unr1

          View more View less

          UniProt ID: (Human) Q13133, (Mouse) Q9Z0Y9

          View more View less

          Entrez Gene ID: (Human) 10062, (Mouse) 22259, (Rat) 58852

          View more View less

          Function(s)
          DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding cholesterol binding sterol response element binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding metal ion binding retinoid X receptor binding protein heterodimerization activity
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter fatty acid biosynthetic process positive regulation of triglyceride biosynthetic process positive regulation of receptor biosynthetic process positive regulation of cholesterol efflux negative regulation of cholesterol storage intracellular receptor signaling pathway positive regulation of cellular protein metabolic process negative regulation of lipid transport positive regulation of cholesterol transport response to progesterone positive regulation of toll-like receptor 4 signaling pathway cholesterol homeostasis negative regulation of macrophage activation apoptotic cell clearance steroid hormone mediated signaling pathway cellular lipid metabolic process positive regulation of fatty acid biosynthetic process negative regulation of proteolysis negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of pinocytosis negative regulation of inflammatory response positive regulation of lipoprotein lipase activity lipid homeostasis sterol homeostasis triglyceride homeostasis cellular response to lipopolysaccharide negative regulation of pancreatic juice secretion negative regulation of secretion of lysosomal enzymes regulation of cholesterol homeostasis positive regulation of cholesterol homeostasis transcription initiation from RNA polymerase II promoter negative regulation of macrophage derived foam cell differentiation regulation of circadian rhythm negative regulation of interferon-gamma-mediated signaling pathway lipid metabolic process insulin receptor signaling pathway
          It has to be done as per old AB suggested Products section.
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