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Product Details
66494-1-IG
Product Specifications
Species Reactivity
Mouse,
Pig
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G1D9
Immunogen
NR2E3 Fusion Protein Ag5831 (1-322 aa encoded by BC041421)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MCPVDKAHR NQCQACRLKK CLQAGMNQDA VQNERQPRST AQVHLDSMES NTESRPESLV APPAPAGRSP RGPTPMSAAR ALGHHFMASL ITAETCAKLE PEDADENIDV TSNDPEFPSS PYSSSSPCGL DSIHETSARL LFMAVKWAKN LPVFSSLPFR DQVILLEEAW SELFLLGAIQ WSLPLDSCPL LAPPEASAAG GAQGRLTLAS METRVLQETI SRFRALAVDP TEFACMKALV LFKPETRGLK DPEHVEALQD QSQVMLSQHS KAHHPSQPVR FGKLLLLLPS LRFITAERIE LLFFRKTIGN TPMEKLLCDM FKN (1-322 aa encoded by BC041421)
Target Information
NR2E3, a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in NR2E3 results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in NR2E3 has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. NR2E3 is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC138414; MGC138416; Nuclear receptor subfamily 2 group E member 3; Photoreceptor-specific nuclear receptor; Retina-specific nuclear receptor; retinal degeneration 7; RP11-295F4.5; taR-5
Gene Aliases: A930035N01Rik; Nr2e3; PNR; rd7; RNR
UniProt ID: (Mouse) Q9QXZ7
Entrez Gene ID: (Mouse) 23958
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of cell proliferation
eye photoreceptor cell development
steroid hormone mediated signaling pathway
positive regulation of rhodopsin gene expression
positive regulation of transcription from RNA polymerase II promoter
retina development in camera-type eye
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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