Proteintech

NR4A3 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

55405-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:600
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

260 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Aliquoting is unnecessary for -20°C storage.

Target Information

NOR-1, a NR4 nerve growth factor-like receptor, has been shown to affect neuronal development, T-cell apoptosis, and cancer development. NOR-1 binds to NBRE (NGFI-B response element) and regulates the pro-opiomelanocortin (POMC) gene. NOR-1 is induced rapidly but transiently by a variety of stimuli. Downregulation of NOR-1 and other NGFI-B family members is correlated with drug addiction-prone behavior of Lewis rats. Three human protein isoforms have been documented: NOR-1, NOR-1beta, and NOR-1 3' variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: chondrosarcoma, extraskeletal myxoid, fused to EWS; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1; Nuclear receptor subfamily 4 group A member 3; nuclear receptor subfamily 4, group A, member 3; Orphan nuclear receptor TEC; TEC receptor; Translocated in extraskeletal chondrosarcoma

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Gene Aliases: AI573420; CHN; CSMF; MINOR; NOR-1; NOR1; NR4A3; TEC

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UniProt ID: (Human) Q92570, (Mouse) Q9QZB6

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Entrez Gene ID: (Human) 8013, (Mouse) 18124

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator binding DNA binding steroid hormone receptor activity thyroid hormone receptor activity protein binding zinc ion binding protein kinase binding histone acetyltransferase binding glucocorticoid receptor binding protein homodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter mesoderm formation transcription initiation from RNA polymerase II promoter gastrulation axon guidance biological_process pyruvate oxidation positive regulation of cardiac muscle hypertrophy positive regulation of glucose transport hippocampus development intracellular receptor signaling pathway adult behavior organ regeneration positive regulation of mast cell cytokine production common myeloid progenitor cell proliferation positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway response to hydrogen peroxide mast cell degranulation steroid hormone mediated signaling pathway negative regulation of neuron apoptotic process cellular response to leptin stimulus cellular respiration fat cell differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of fatty acid oxidation regulation of smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation semicircular canal morphogenesis positive regulation of epithelial cell proliferation neuromuscular process controlling balance vestibular reflex regulation of type B pancreatic cell proliferation cellular response to corticotropin-releasing hormone stimulus cellular response to catecholamine stimulus energy homeostasis positive regulation of monocyte aggregation negative regulation of hydrogen peroxide-induced neuron death positive regulation of leukocyte apoptotic process positive regulation of feeding behavior regulation of energy homeostasis
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