Invitrogen

NR5A2 Polyclonal Antibody

View all (15) NR5A2 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-110041

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 300-541 of human NR5A2 (NP_9955821)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.81 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2855452

Product Specific Information

Immunogen sequence: SIPHLILELL KCEPDEPQVQ AKIMAYLQQE QANRSKHEKL STFGLMCKMA DQTLFSIVEW ARSSIFFREL KVDDQMKLLQ NCWSELLILD HIYRQVVHGK EGSIFLVTGQ QVDYSIIASQ AGATLNNLMS HAQELVAKLR SLQFDQREFV CLKFLVLFSL DVKNLENFQL VEGVQEQVNA ALLDYTMCNY PQQTEKFGQL LLRLPEIRAI SMQAEEYLYY KHLNGDVPYN NLLIEMLHAK RA

Target Information

Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Alpha-1-fetoprotein transcription factor; B1-binding factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus; CYP7A promoter-binding factor; Fetoprotein transcription factor; fetoprotein-alpha 1 (AFP) transcription factor; FTZ F1; FTZ F1beta; FTZ-F1 beta; FTZ-F1 beta2 protein; hB1F; hB1F 2; Hepatocytic transcription factor; hepatocytic transcription factor hB1F-3; live; liver nuclear receptor homolog-1 variant 2; Liver receptor homolog 1; LRH-1; mFTF; Nuclear receptor subfamily 5 group A member 2; nuclear receptor subfamily 5, group A, member 2

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Gene Aliases: AU020803; B1F; B1F2; CPF; D1Ertd308e; FTF; FTZ-F1; FTZ-F1beta; hB1F-2; LRH-1; LRH1; NR5A2; UF2-H3B

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UniProt ID: (Human) O00482, (Rat) Q9QWM1, (Mouse) P45448

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Entrez Gene ID: (Human) 2494, (Rat) 60349, (Mouse) 26424

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding phospholipid binding zinc ion binding sequence-specific DNA binding transcription regulatory region DNA binding double-stranded DNA binding lipid binding metal ion binding
Process(es)
transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter bile acid metabolic process intracellular receptor signaling pathway epithelial cell differentiation regulation of cell proliferation cholesterol homeostasis steroid hormone mediated signaling pathway positive regulation of viral genome replication positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter pancreas morphogenesis regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter hormone-mediated signaling pathway embryo development tissue development homeostatic process
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