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Invitrogen
NRBF2 Polyclonal Antibody
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Product Details
PA5-92994
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-287 of human NRBF2 (NP_1103862)
Conjugate
Form
Liquid
Concentration
2.03 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2806576
Product Specific Information
Immunogen sequence: MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS EQAHLSLELQ RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE GQSPLSQKYS PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA PKDDKTIIEE QATKIADLKR HVEFLVAENE RLRKENKQLK AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS STWQKFAANT GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN
Positive Samples: SKOV3, HepG2, 293T, HeLa, Jurkat, Mouse brain, Mouse heart, Rat brain; Cellular Location: Cytoplasm, Cytoplasmic vesicle, Nucleus, autophagosome
Target Information
NRBF2 (nuclear receptor-binding factor 2) modulates transcriptional activation by target nuclear receptors. It is involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). NRBF2 stabilizes the PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Comodulator of PPAR and RXR; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; NRBF-2; nuclear receptor binding factor-2; Nuclear receptor-binding factor 2
Gene Aliases: COPR; COPR1; COPR2; NRBF-2; NRBF2
UniProt ID: (Human) Q96F24, (Rat) Q9QYK3, (Mouse) Q8VCQ3
Entrez Gene ID: (Human) 29982, (Rat) 58839, (Mouse) 641340
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
autophagy
regulation of autophagy
response to endoplasmic reticulum stress
regulation of lipid kinase activity
transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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