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Invitrogen
NRBF2 Recombinant Rabbit Monoclonal Antibody (15H7L3)
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FIGURE: 1 / 3
NRBF2 Antibody (702920) in WB
Western blot analysis was performed on modified whole cell extracts (1% SDS) (30 µg lysate) of MCF7 (Lane 1), MDA-MB-231 (Lane 4), T-47D (Lane 5), A-375 (Lane 6), Hep G2 (Lane 7) and tissue extracts of Mouse Brain (Lane 2) and Rat Brain (Lane 3). The blot was probed with Anti-NRBF2 Recombinant Rabbit Monoclonal Antibody (Product # 702920, 1:5000 dilution) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.25 µg/mL, 1:4000 dilution). A 36 kDa band co... View More
Product Details
702920
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
15H7L3
Immunogen
Protein corresponding to human NRBF2 [aa4-aa90]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2734822
Product Specific Information
This antibody is predicted to react with Monkey, Sheep, Bovine, Pig.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
NRBF2 (nuclear receptor-binding factor 2) modulates transcriptional activation by target nuclear receptors. It is involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). NRBF2 stabilizes the PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Comodulator of PPAR and RXR; comodulator of PPAR and RXR 1; comodulator of PPAR and RXR 2; NRBF-2; nuclear receptor binding factor-2; Nuclear receptor-binding factor 2
Gene Aliases: COPR; COPR1; COPR2; NRBF-2; NRBF2
UniProt ID: (Human) Q96F24, (Rat) Q9QYK3, (Mouse) Q8VCQ3
Entrez Gene ID: (Human) 29982, (Rat) 58839, (Mouse) 641340
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
autophagy
regulation of autophagy
response to endoplasmic reticulum stress
regulation of lipid kinase activity
transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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