Invitrogen

NRG1 Polyclonal Antibody

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View all (28) NRG1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-78627

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of mouse Neuregulin-1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.71 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2736257

Product Specific Information

Positive Control: mouse brain, rat brain

Predicted reactivity: Mouse (100%), Rat (94%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. It is known that an extraordinary variety of different isoforms are produced from the NRG1 gene by alternative splicing. These isoforms include heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF). They are tissue-specifically expressed and differ significantly in their structure. The HRG isoforms all contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF isoform shares only the EGF-like domain with other isoforms. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: heregulin; neuregulin 1 type III beta 3; NRG-1; pro-neuregulin-1, membrane-bound isoform; pro-NRG1; type I neuregulin 1; type III neuregulin 1

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Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGFII; Hgl; HRG; HRGalpha; NDF; SMDF

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Entrez Gene ID: (Rat) 112400, (Mouse) 211323

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Function(s)
transcription cofactor activity receptor binding ErbB-2 class receptor binding growth factor activity protein tyrosine kinase activator activity ErbB-3 class receptor binding
Process(es)
MAPK cascade cell morphogenesis cardiac conduction system development ventricular trabecula myocardium morphogenesis transmembrane receptor protein tyrosine kinase signaling pathway activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development heart development muscle organ development locomotory behavior regulation of blood pressure cell proliferation glial cell differentiation negative regulation of cardiac muscle cell apoptotic process glucose transport cell migration glial cell fate commitment cell differentiation positive regulation of cell growth intracellular signal transduction ERBB signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein heterodimerization activity cellular protein complex disassembly neurotransmitter receptor metabolic process regulation of cell differentiation positive regulation of cell adhesion positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of Ras protein signal transduction animal organ development neuron fate commitment negative regulation of secretion positive regulation of protein kinase B signaling ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade positive regulation of cardiac muscle cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand axon ensheathment positive regulation of myelination oligodendrocyte differentiation
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