Alomone Labs, LTD

NRG1 Type III (extracellular) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ANR-113-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)DKIFEYDSPTHLD, corresponding to amino acid residues 101-113 of human Neuregulin-1 Type III, Extracellular
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

Neuregulin-1 (Nrg1)/erbB signaling regulates neuronal development, migration, myelination, and synaptic maintenance. The expression of NRG1 type III expression have been studied in the adult brain, the medial prefrontal cortex, ventral hippocampus, and ventral subiculum. Expression of NRG1 type III expressio in these regions are involved in the regulation of sensorimotor gating and short-term memory.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); III Type NRG1; neu differentiation factor; neuregulin 1 type III beta 3; Neuregulin-1 Type III; NRG-1 Type III; NRG1 Type 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1

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Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

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UniProt ID: (Human) P98202

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Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323

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Function(s)
transcription cofactor activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity ErbB-2 class receptor binding integrin binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding protein tyrosine kinase activator activity
Process(es)
MAPK cascade cell morphogenesis cardiac conduction system development ventricular trabecula myocardium morphogenesis transmembrane receptor protein tyrosine kinase signaling pathway activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development heart development muscle organ development locomotory behavior regulation of blood pressure cell proliferation glial cell differentiation negative regulation of cardiac muscle cell apoptotic process glucose transport cell migration glial cell fate commitment cell differentiation positive regulation of cell growth intracellular signal transduction ERBB signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein heterodimerization activity cellular protein complex disassembly neurotransmitter receptor metabolic process regulation of cell differentiation positive regulation of cell adhesion positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of Ras protein signal transduction animal organ development neuron fate commitment negative regulation of secretion positive regulation of protein kinase B signaling ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of protein tyrosine kinase activity positive regulation of calcineurin-NFAT signaling cascade positive regulation of cardiac muscle cell differentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand activation of MAPK activity startle response cell communication positive regulation of cell proliferation embryo development neural crest cell development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development positive regulation of myelination activation of protein kinase B activity ERBB2 signaling pathway regulation of protein homodimerization activity positive regulation of GTPase activity positive regulation of axon extension positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of striated muscle cell differentiation cardiac muscle cell differentiation positive regulation of dendritic spine development positive regulation of protein targeting to mitochondrion positive regulation of protein localization to cell surface regulation of cell motility negative regulation of neuron migration axon ensheathment
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