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Product Details
PA5-68427
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues near the C terminal of human NRG2.
Conjugate
Form
Liquid
Concentration
1.6 mg/mL
Purification
affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2688556
Target Information
Neuregulin 2 is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2
Gene Aliases: DON1; HRG2; NRG2; NTAK
UniProt ID: (Human) O14511
Entrez Gene ID: (Human) 9542
MAPK cascade
signal transduction
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
intracellular signal transduction
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
animal organ development
regulation of cell motility
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