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NRG2 Antibody (PA5-95030) in WB
Western blot analysis of NRG2 in Lane 1: rat liver tissue lysate (50 µg), Lane 2: COLO320 whole cell lysate (40 µg), Lane 3: SMMC whole cell lysate (40 µg), Lane 4: SW620 whole cell lysate (40 µg). Samples were incubated with NRG2 polyclonal antibody (Product # PA5-95030).
Product Details
PA5-95030
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human NRG2 (289-306aa NGRKNSRLQFNKVKVEDA).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2806836
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Liver Tissue, COLO320 whole cell, SMMC whole cell, SW620 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
Neuregulin 2 is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases; NTAK alpha1; Pro-neuregulin-2, membrane-bound isoform; Pro-NRG2
Gene Aliases: DON1; HRG2; NRG2; NTAK; NTAK_alpha2a
UniProt ID: (Human) O14511, (Rat) O35569
Entrez Gene ID: (Human) 9542, (Rat) 432361, (Mouse) 100042150
epidermal growth factor receptor signaling pathway
intracellular signal transduction
animal organ development
MAPK cascade
signal transduction
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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