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NRG4 Antibody (PA5-96184) in IHC (P)
Immunohistochemistry analysis of NRG4 in paraffin-embedded human stomach. Samples were incubated with NRG4 Polyclonal antibody (Product # PA5-96184) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96184
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NRG4 (NP_6126401)
Conjugate
Form
Liquid
Concentration
1.36 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807986
Product Specific Information
Positive Samples: Cellular Location: Cell membrane, Single-pass type I membrane protein
Immunogen sequence: RKGHFQRASS VQ
Target Information
Neuregulin 4 (NRG4) is a member of the Neuregulin family serving as a ligand for the epidermal growth factor receptor (EGFR) family, specifically interacting with ERBB4. This gene is primarily expressed in brown adipose tissue and liver, where it plays a pivotal role in metabolic regulation. NRG4 acts as a critical signaling molecule in adipose tissue, promoting systemic glucose homeostasis and energy expenditure while inhibiting hepatic lipogenesis, thereby contributing to protection against diet-induced obesity and insulin resistance. Moreover, NRG4 expression is inversely correlated with adiposity and positively correlated with insulin sensitivity, suggesting its potential role in metabolic homeostasis. Studies reveal that NRG4's interaction with ERBB4 stimulates specific cellular pathways, which can impact hepatic gluconeogenesis, underscoring its importance in glucose metabolism. Additionally, NRG4 has been linked to breast cancer progression, where it contributes to tumor cell survival through signaling pathways involving receptor tyrosine kinases. Due to its significant involvement in metabolic pathways and cancer biology, NRG4 is considered a promising target for therapeutic intervention in metabolic disorders and certain cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heregulin 4; Pro-neuregulin-4, membrane-bound isoform; Pro-NRG4
Gene Aliases: AI552600; HRG4; NRG4
UniProt ID: (Human) Q8WWG1, (Mouse) Q9WTX4
Entrez Gene ID: (Human) 145957, (Mouse) 83961, (Rat) 690919
intracellular signal transduction
animal organ development
MAPK cascade
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
ERBB2 signaling pathway
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
regulation of cell motility
biological_process
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