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Bioss
NSE1 Polyclonal Antibody
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Product Details
BS-11010R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NSE1/FAM84A, amino acids 151-250.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The FAM84A gene, also known as Family With Sequence Similarity 84 Member A, is located on chromosome 1q21.3. This gene encodes a protein that has been implicated in the development and progression of various cancers. In particular, FAM84A has been identified as a key player in the epithelial-mesenchymal transition (EMT) and Wnt/beta-catenin signaling pathways, which are crucial for tumor development and metastasis. Studies have shown that the downregulation of FAM84A can inhibit thyroid cancer progression while being negatively regulated by the tumor suppressor miR-874-3p. Additionally, FAM84A has been noted to be over-expressed in phenobarbital-promoted mouse liver tumors, indicating its potential role in chemical carcinogenesis. The gene's expression is regulated by nuclear receptor CAR, highlighting its involvement in liver cancer pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: family with sequence similarity 84, member A; LRAT domain-containing 1; Neurologic sensory protein 1; neurological/sensory 1; NSE1; Protein FAM84A; Protein LRATD1
Gene Aliases: 2310003N02Rik; 4731402F03Rik; AW125753; FAM84A; LRATD1; NSE1; PP11517; RGD1305779
UniProt ID: (Human) Q96KN4, (Mouse) Q9D650
Entrez Gene ID: (Human) 151354, (Rat) 313969, (Mouse) 105005
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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