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Abnova
NSE1 Monoclonal Antibody (1C2)
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Product Details
H00151354-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
1C2
Immunogen
NSE1 (AAH26346, 1 a.a. approximately 292 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: MGNQLDRITH LNYSELPTGD PSGIEKDELR VGVAYFFSDD EEDLDERGQP DKFGVKAPPG CTPCPESPSR HHHHLLHQLV LNETQFSAFR GQECIFSKVS GGPQGADLSV YAVTALPALC EPGDLLELLW LQHAPEPPAP APHWAVYVGG GQIIHLHQGE IRQDSLYEAG AANVGRVVNS WYRYRPLVAE LVVQNACGHL GLKSEEICWT NSESFAAWCR FGKREFKAGG EVPAGTQPPQ QQYYLKVHLG ENKVHTARFH SLEDLIREKR RIDASGRLRV LQELADLVDD KE
Target Information
The FAM84A gene, also known as Family With Sequence Similarity 84 Member A, is located on chromosome 1q21.3. This gene encodes a protein that has been implicated in the development and progression of various cancers. In particular, FAM84A has been identified as a key player in the epithelial-mesenchymal transition (EMT) and Wnt/beta-catenin signaling pathways, which are crucial for tumor development and metastasis. Studies have shown that the downregulation of FAM84A can inhibit thyroid cancer progression while being negatively regulated by the tumor suppressor miR-874-3p. Additionally, FAM84A has been noted to be over-expressed in phenobarbital-promoted mouse liver tumors, indicating its potential role in chemical carcinogenesis. The gene's expression is regulated by nuclear receptor CAR, highlighting its involvement in liver cancer pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: family with sequence similarity 84, member A; LRAT domain-containing 1; Neurologic sensory protein 1; neurological/sensory 1; NSE1; Protein FAM84A; Protein LRATD1
Gene Aliases: FAM84A; LRATD1; NSE1; PP11517
UniProt ID: (Human) Q96KN4
Entrez Gene ID: (Human) 151354
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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