Proteintech

NSUN6 Polyclonal Antibody

4 References
View all (5) NSUN6 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

17240-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NSUN6 Fusion Protein Ag11084 (118-469 aa encoded by BC035778)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AQCGNAVLR GAHVYAPGIV SASQFMKAGD VISVYSDIKG KCKKGAKEFD GTKVFLGNGI SELSRKEIFS GLPELKGMGI RMTEPVYLSP SFDSVLPRYL FLQNLPSALV SHVLNPQPGE KILDLCAAPG GKTTHIAALM HDQGEVIALD KIFNKVEKIK QNALLLGLNS IRAFCFDGTK AVKLDMVEDT EGEPPFLPES FDRILLDAPC SGMGQRPNMA CTWSVKEVAS YQPLQRKLFT AAVQLLKPEG VLVYSTCTIT LAENEEQVAW ALTKFPCLQL QPQEPQIGGE GMRGAGLSCE QLKQLQRFDP SAVPLPDTDM DSLREARRED MLRLANKDSI GFFIAKFVKC KST (118-469 aa encoded by BC035778)

Target Information

NSun6 is an RNA methyltransferase that catalyzes the methylation at position cytosine C72 in some tRNAs. NSUN6 has been reported to localize to the cytoplasm and largely colocalize with Golgi apparatus and pericentriolar matrix, indicating that NSUN6 modifies tRNAs in a late step in their biogenesis. NSun6 may also play a major role in bone metastasis and could be a valuable therapeutic target for bone metastasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ARL5B antisense RNA 1; NOL1/NOP2/Sun and PUA domain-containing protein 1; NOL1/NOP2/Sun domain family 6; NOL1/NOP2/Sun domain family member 6; NOL1/NOP2/Sun domain family, member 6; NOP2/Sun domain family, member 6; nucleolar protein (NOL1/NOP2/sun) and PUA domains 1; putative methyltransferase NSUN6; tRNA (cytosine(72)-C(5))-methyltransferase NSUN6

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Gene Aliases: 4933403D21Rik; 4933414E04Rik; ARL5B-AS1; NOPD1; NSUN6

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UniProt ID: (Human) Q8TEA1, (Mouse) Q7TS68

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Entrez Gene ID: (Human) 221078, (Rat) 307148, (Mouse) 74455

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Function(s)
tRNA binding RNA methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity RNA binding methyltransferase activity rRNA (adenine-N6,N6-)-dimethyltransferase activity molecular_function protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity protein-arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity
Process(es)
methylation biological_process RNA methylation tRNA methylation
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