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Purine 5-prime-nucleotidase (EC 3.1.3.5) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides, and is allosterically activated by various compounds, including ATP. The enzyme is exclusively located in the cytoplasmic matrix of cells and may have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases.
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Protein Aliases: 5'-nucleotidase (purine), cytosolic type B; 5'-nucleotidase, cytosolic II; cN-II; Cytosolic 5'-nucleotidase II; Cytosolic IMP/GMP-specific 5'-nucleotidase; Cytosolic nucleoside phosphotransferase 5'N; Cytosolic purine 5'-nucleotidase; High Km 5'-nucleotidase; IMP-specific 5'-NT; RP11-30H12.3
Gene Aliases: 2010002I23Rik; cN-II; CnII; ENSMUSG00000025039; Gm9751; GMP; NT5B; NT5C2; NT5CP; PNT5; SPG45; SPG65
UniProt ID: (Human) P49902, (Mouse) Q3V1L4
Entrez Gene ID: (Human) 22978, (Mouse) 76952, (Rat) 100363253
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