Invitrogen

NTF3 Polyclonal Antibody

View all (31) NTF3 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-96235

Applications
Tested Dilution
Publications

Western Blot (WB)

1:50-1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 19-257 of human NTF3 (NP_0025181)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.9 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2808037

Product Specific Information

Positive Samples: Mouse heart

Immunogen sequence: NNMDQRSLPE DSLNSLIIKL IQADILKNKL SKQMVDVKEN YQSTLPKAEA PREPERGGPA KSAFQPVIAM DTELLRQQRR YNSPRVLLSD STPLEPPPLY LMEDYVGSPV VANRTSRRKR YAEHKSHRGE YSVCDSESLW VTDKSSAIDI RGHQVTVLGE IKTGNSPVKQ YFYETRCKEA RPVKNGCRGI DDKHWNSQCK TSQTYVRALT SENNKLVGWR WIRIDTSCVC ALSRKIGRT

Target Information

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HDNF; Nerve growth factor 2; Neurotrophic factor; Neurotrophin-3; NGF-2; NT-3

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Gene Aliases: AI316846; AI835689; HDNF; NGF-2; NGF2; NT-3; NT3; Ntf-3; NTF3

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UniProt ID: (Human) P20783, (Mouse) P20181

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Entrez Gene ID: (Human) 4908, (Mouse) 18205

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Function(s)
receptor binding neurotrophin p75 receptor binding protein binding growth factor activity chemoattractant activity nerve growth factor binding neurotrophin receptor binding
Process(es)
activation of MAPK activity positive regulation of receptor internalization transmembrane receptor protein tyrosine kinase signaling pathway neuromuscular synaptic transmission nervous system development glial cell fate determination axon guidance brain development peripheral nervous system development positive regulation of cell proliferation epidermis development nerve development positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation mechanoreceptor differentiation myelination regulation of apoptotic process regulation of neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of transcription from RNA polymerase II promoter enteric nervous system development neuron development generation of neurons neuron projection morphogenesis positive regulation of peptidyl-tyrosine phosphorylation negative regulation of peptidyl-tyrosine phosphorylation modulation of synaptic transmission positive chemotaxis induction of positive chemotaxis smooth muscle cell differentiation activation of GTPase activity positive regulation of actin cytoskeleton reorganization signal transduction cell-cell signaling
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