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Invitrogen
NTF3 Monoclonal Antibody (OTI5C7)
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NTF3 Antibody (MA5-24892) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of breast tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a NTF3 monoclonal antibody (Product # MA5-24892).
Product Details
MA5-24892
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
OTI5C7
Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 139-257 of NT3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2724877
Target Information
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HDNF; Nerve growth factor 2; Neurotrophic factor; Neurotrophin-3; NGF-2; NT-3
Gene Aliases: HDNF; NGF-2; NGF2; NT-3; NT3; NTF3
UniProt ID: (Human) P20783
Entrez Gene ID: (Human) 4908
activation of MAPK activity
positive regulation of receptor internalization
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell-cell signaling
nervous system development
positive regulation of cell proliferation
positive regulation of cell migration
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
myelination
regulation of apoptotic process
negative regulation of neuron apoptotic process
regulation of neuron differentiation
positive regulation of glial cell differentiation
neuron projection morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
modulation of synaptic transmission
positive chemotaxis
induction of positive chemotaxis
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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