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Proteintech
NTHL1 Polyclonal Antibody
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Product Details
14918-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NTHL1 Fusion Protein Ag6734 (2-305 aa encoded by BC000391)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTALSARML TRSRSLGPGA GPRGCREEPG PLRRREAAAE ARKSHSPVKR PRKAQRLRVA YEGSDSEKGE GAEPLKVPVW EPQDWQQQLV NIRAMRNKKD APVDHLGTEH CYDSSAPPKV RRYQVLLSLM LSSQTKDQVT AGAMQRLRAR GLTVDSILQT DDATLGKLIY PVGFWRSKVK YIKQTSAILQ QHYGGDIPAS VAELVALPGV GPKMAHLAMA VAWGTVSGIA VDTHVHRIAN RLRWTKKATK SPEETRAALE EWLPRELWHE INGLLVGFGQ QTCLPVHPRC HACLNQALCP AAQGL (2-305 aa encoded by BC000391)
Target Information
Oxygen radicals damage chromosonal DNA causing cell death and inducing mutations. Although a major focus of oxidatively damaged DNA has centered on the repair of 8-oxo-G, a number of other damaged DNA sites are created by free-radical attack on DNA. The human NTH1 repair protein is one enzyme that has been shown to act on a large number of these other oxidatively damaged DNA sites.A homologue of E. coli Endonuclease III, NTH is a DNA glycosylase with apurinic/apyrimidinic lyase activity. The NTH protein has broad substrate specificity, including numerous ring saturation and fragmentation products of pyrimidines. Research indicates NTH plays a crucial role in removal of oxidative base lesions in mitochondrial DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; Endonuclease III-like protein 1; hNTH1; nth endonuclease III-like 1; NTHL 1; OCTS 3; thymine glycol DNA glycosylase/AP lyase
Gene Aliases: FAP3; hNTH1; NTH1; NTHL1; OCTS3
UniProt ID: (Human) P78549, (Mouse) O35980
Entrez Gene ID: (Human) 4913, (Mouse) 18207, (Rat) 29541
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
double-stranded DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
endonuclease activity
protein binding
oxidized purine nucleobase lesion DNA N-glycosylase activity
DNA N-glycosylase activity
metal ion binding
4 iron, 4 sulfur cluster binding
purine-specific mismatch base pair DNA N-glycosylase activity
DNA binding
catalytic activity
uracil DNA N-glycosylase activity
hydrolase activity
hydrolase activity, acting on glycosyl bonds
lyase activity
single-strand selective uracil DNA N-glycosylase activity
DNA-3-methylbase glycosylase activity
iron-sulfur cluster binding
nicotinamide riboside hydrolase activity
nicotinic acid riboside hydrolase activity
deoxyribonucleoside 5'-monophosphate N-glycosidase activity
positive regulation of defense response to virus by host
DNA repair
base-excision repair
base-excision repair, AP site formation
nucleotide-excision repair, DNA incision, 5'-to lesion
cellular response to DNA damage stimulus
metabolic process
mitophagy in response to mitochondrial depolarization
DNA catabolic process, endonucleolytic
depyrimidination
xenophagy
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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