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Product Details
H00009423-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
5H8
Immunogen
NTN1 (NP_004813, 495 a.a. approximately 604 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: YAVQIHILKA DKAGDWWKFT VNIISVYKQG TSRIRRGDQS LWIRSRDIAC KCPKIKPLKK YLLLGNAEDS PDQSGIVADK SSLVIQWRDT WARRLRKFQQ REKKGKCKKA
Target Information
Netrin-G1 ligand (NGL1) is a transmembrane protein containing leucine-rich repeat (LRR) and immunoglobulin (Ig) domains that specifically interact with netrin-G1 through its LRR region. Whereas netrin-G1 is expressed highly in mouse thalamic axons, NGL1 is most abundant in the striatum and the cerebral cortex. NGL1 is implicated in facilitating axonal growth of the vertebrate CNS. Membrane-bound netrin-G1 acts as an axonal receptor, whereas the LRR-containing transmembrane protein NGL1 acts as a ligand in promoting the growth of thalamic axons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Epididymis tissue protein Li 131P; HGNC:8029; netrin 1, mouse, homolog of; Netrin-1; Netrin1
Gene Aliases: NTN1; NTN1L
UniProt ID: (Human) O95631
Entrez Gene ID: (Human) 9423
neuron migration
apoptotic process
substrate-dependent cell migration, cell extension
Ras protein signal transduction
axon guidance
positive regulation of cell proliferation
single organismal cell-cell adhesion
regulation of cell migration
negative regulation of axon extension
Cdc42 protein signal transduction
anterior/posterior axon guidance
establishment of nucleus localization
inner ear morphogenesis
positive regulation of axon extension
mammary gland duct morphogenesis
positive regulation of cell motility
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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