OriGene

NUDT4 Monoclonal Antibody (OTI1C2), TrueMAB™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CF809679

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI1C2

Immunogen

Full length human recombinant protein of human NUDT4 produced in E.coli.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5-phosphoribose 1-diphosphate. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2; diphosphoinositol polyphosphate phosphohydolase type II; Diphosphoinositol polyphosphate phosphohydrolase 2; Diphosphoinositol polyphosphate phosphohydrolase NUDT4B; diphosphoinositol polyphosphate phosphohydrolase type 2; DIPP-2; DIPP-2B; Nucleoside diphosphate-linked moiety X motif 4; Nucleoside diphosphate-linked moiety X motif 4B; nudix (nucleoside diphosphate linked moiety X)-type motif 4; Nudix hydrolase 4B; Nudix motif 4; Nudix motif 4B; nudix-type motif 4; rDIPP2

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Gene Aliases: 4933436C10Rik; DIPP2; DIPP2alpha; DIPP2beta; DRCF-5; HDCMB47P; KIAA0487; NUDT4; NUDT4B

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UniProt ID: (Human) A0A024RBG1, (Mouse) Q8R2U6, (Rat) Q99MY2

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Entrez Gene ID: (Human) 11163, (Mouse) 71207, (Rat) 94267

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Function(s)
protein binding diphosphoinositol-polyphosphate diphosphatase activity snoRNA binding metal ion binding m7G(5')pppN diphosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity RNA binding thiamine-pyrophosphatase activity 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity UDP-2,3-diacylglucosamine hydrolase activity bis(5'-nucleosyl)-tetraphosphatase activity dATP pyrophosphohydrolase activity pyrophosphatase activity hydrolase activity dihydroneopterin monophosphate phosphatase activity dihydroneopterin triphosphate pyrophosphohydrolase activity dITP diphosphatase activity dTTP diphosphatase activity XTP diphosphatase activity ATP-dependent 5'-3' DNA helicase activity phosphocholine hydrolase activity
Process(es)
phosphatidylinositol metabolic process cyclic nucleotide metabolic process calcium-mediated signaling cyclic-nucleotide-mediated signaling intracellular signal transduction inositol phosphate metabolic process regulation of RNA export from nucleus intracellular transport
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