Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
H00004928-B02P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NUP98 (AAH12906.1, 1 a.a. approximately 606 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MKLYQTPLEL KLKHSTVHVD ELCPLIVPNL GVAVIHDYAD WVKEASGDLP EAQIVKHWSL TWTLCEALWG HLKELDSQLN EPREYIQILE RRRAFSRWLS CTATPQIEEE VSLTQKNSPV EAVFSYLTGK RISEACSLAQ QSGDHRLALL LSQFVGSQSV RELLTMQLVD WHQLQADSFI QDERLRIFAL LAGKPVWQLS EKKQINVCSQ LDWKRSLAIH LWYLLPPTAS ISRALSMYEE AFQNTSDSDR YACSPLPSYL EGSGCVIAEE QNSQTPLRDV CFHLLKLYSD RHYDLNQLLE PRSITADPLD YRLSWHLWEV LRALNYTHLS AQCEGVLQAS YAGQLESEGL WEWAIFVLLH IDNSGIREKA VRELLTRHCQ LLETPESWAK ETFLTQKLRV PAKWIHEAKA VRAHMESDKH LEALCLFKAE HWNRCHKLII RHLASDAIIN ENYDYLKGFL EDLAPPERSS LIQDWETSGL VYLDYIRVIE MLRHIQQVDC SGNDLEQLHI KVTSLCSRIE QIQCYSAKDR LAQSDMAKRV ANLLRVVLSL HHPPDRTSDS TPDPQRVPLR LLAPHIGRLP MPEDYAMDEL RSLTQSYLRE LAVGSL
Target Information
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup98-Nup96; nucleoporin 98kD; nucleoporin 98kDa; Nup98-Nup96; NUP98/PHF23 fusion 2 protein; OTTHUMP00000013954
Gene Aliases: ADAR2; ADIR2; NUP196; NUP96; NUP98
UniProt ID: (Human) P52948
Entrez Gene ID: (Human) 4928
protein import into nucleus, docking
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
DNA replication
RNA export from nucleus
mRNA export from nucleus
tRNA export from nucleus
nucleocytoplasmic transport
nuclear pore organization
sister chromatid cohesion
mitotic nuclear envelope disassembly
regulation of glucose transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
telomere tethering at nuclear periphery
nuclear pore complex assembly
intracellular transport of virus
regulation of cellular response to heat
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support